New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi; Hanieh Yaghootkar; Dennis O. Mook-Kanamori; Ulla Sovio; H. Rob Taal; Branwen J. Hennig; Jonathan P. Bradfield; Beate St Pourcain; David M. Evans; Pimphen Charoen; Marika Kaakinen; Diana L. Cousminer; Terho Lehtimaki; Eskil Kreiner-Moller; Nicole M. Warrington; Mariona Bustamante; Bjarke Feenstra; Diane J. Berry; Elisabeth Thiering; Thiemo Pfab; Sheila J. Barton; Beverley M. Shields; Marjan Kerkhof; Elisabeth M. van Leeuwen; Anthony J. Fulford; Zoltan Kutalik; Jing Hua Zhao; Marcel den Hoed; Anubha Mahajan; Virpi Lindi; Liang-Kee Goh; Jouke-Jan Hottenga; Ying Wu; Olli T. Raitakari; Marie N. Harder; Aline Meirhaeghe; Ioanna Ntalla; Rany M. Salem; Karen A. Jameson; Kaixin Zhou; Dorota M. Monies; Vasiliki Lagou; Mirna Kirin; Jani Heikkinen; Linda S. Adair; Fowzan S. Alkuraya; Ali Al-Odaib; Philippe Amouyel; Ehm Astrid Andersson; Amanda J. Bennett; Alexandra I. F. Blakemore; Jessica L. Buxton; Jean Dallongeville; Shikta Das; Eco J. C. de Geus; Xavier Estivill; Claudia Flexeder; Philippe Froguel; Frank Geller; Keith M. Godfrey; Frederic Gottrand; Christopher J. Groves; Torben Hansen; Joel N. Hirschhorn; Albert Hofman; Mads V. Hollegaard; David M. Hougaard; Elina Hyppoenen; Hazel M. Inskip; Aaron Isaacs; Torben Jorgensen; Christina Kanaka-Gantenbein; John P. Kemp; Wieland Kiess; Tuomas O. Kilpelainen; Norman Klopp; Bridget A. Knight; Christopher W. Kuzawa; George McMahon; John P. Newnham; Harri Niinikoski; Ben A. Oostra; Louise Pedersen; Dirkje S. Postma; Susan M. Ring; Fernando Rivadeneira; Neil R. Robertson; Sylvain Sebert; Olli Simell; Torsten Slowinski; Carla M. T. Tiesler; Anke Toenjes; Allan Vaag; Jorma S. Viikari; Jacqueline M. Vink; Nadja Hawwa Vissing; Nicholas J. Wareham; Gonneke Willemsen; Daniel R. Witte; Haitao Zhang; Early Growth Genetics EGG; Inga Prokopenko

doi:10.1038/ng.2477

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Momoko Horikoshi, Hanieh Yaghootkar, Dennis O. Mook-Kanamori, Ulla Sovio, H. Rob Taal, Branwen J. Hennig, Jonathan P. Bradfield, Beate St Pourcain, David M. Evans, Pimphen Charoen, …

Nature genetics, Vol.45(1), pp.76-U115

01/01/2013

DOI: https://doi.org/10.1038/ng.2477

PMID: 23202124

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits(2). In an expanded genome-wide association metaanalysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

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Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Creators: Momoko Horikoshi - Oxford Centre for Diabetes, Endocrinology and Metabolism
Hanieh Yaghootkar - University of Exeter
Dennis O. Mook-Kanamori - Erasmus MC
Ulla Sovio - Imperial College London
H. Rob Taal - Erasmus MC
Branwen J. Hennig - Medical Research Council
Jonathan P. Bradfield - Children's Hospital of Philadelphia
Beate St Pourcain - University of Bristol
David M. Evans - University of Bristol
Pimphen Charoen - Imperial College London
Marika Kaakinen - University of Oulu
Diana L. Cousminer - Institute for Molecular Medicine Finland
Terho Lehtimaki - Tampere University
Eskil Kreiner-Moller - University of Copenhagen
Nicole M. Warrington - University of Western Australia
Mariona Bustamante - Center for Research in Environmental Epidemiology
Bjarke Feenstra - Statens Serum Institut
Diane J. Berry - University College London
Elisabeth Thiering - Helmholtz Zentrum München
Thiemo Pfab - Charité - Universitätsmedizin Berlin
Sheila J. Barton - University of Southampton
Beverley M. Shields - University of Exeter
Marjan Kerkhof - University Medical Center Groningen
Elisabeth M. van Leeuwen - Erasmus MC
Anthony J. Fulford - Medical Research Council
Zoltan Kutalik - University of Lausanne
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Marcel den Hoed - Massachusetts Rehabilitation Commission
Anubha Mahajan - Wellcome Centre for Human Genetics
Virpi Lindi - University of Eastern Finland
Liang-Kee Goh - Duke-NUS Medical School
Jouke-Jan Hottenga - Vrije Universiteit Amsterdam
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Olli T. Raitakari - University of Turku
Marie N. Harder - Novo Nordisk Foundation
Aline Meirhaeghe - Inserm
Ioanna Ntalla - Harokopio University of Athens
Rany M. Salem - Boston Children's Hospital
Karen A. Jameson - MRC Lifecourse Epidemiology Unit
Kaixin Zhou - University of Dundee
Dorota M. Monies - King Faisal Specialist Hospital & Research Centre
Vasiliki Lagou - Wellcome Centre for Human Genetics
Mirna Kirin - University of Edinburgh
Jani Heikkinen - Institute for Molecular Medicine Finland
Linda S. Adair - University of North Carolina at Chapel Hill
Fowzan S. Alkuraya - King Faisal Specialist Hospital & Research Centre
Ali Al-Odaib - King Faisal Specialist Hosp & Res Ctr, Dept Genet, Riyadh 11211, Saudi Arabia
Philippe Amouyel - Inserm
Ehm Astrid Andersson - Novo Nordisk Foundation
Amanda J. Bennett - University of Oxford
Alexandra I. F. Blakemore - Imperial College London
Jessica L. Buxton - Imperial College London
Jean Dallongeville - Inserm
Shikta Das - Imperial College London
Eco J. C. de Geus - Vrije Universiteit Amsterdam
Xavier Estivill - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Claudia Flexeder - Helmholtz Zentrum München
Philippe Froguel - Institut Pasteur de Lille
Frank Geller - Statens Serum Institut
Keith M. Godfrey - MRC Lifecourse Epidemiology Unit
Frederic Gottrand - Inserm
Christopher J. Groves - Oxford Centre for Diabetes, Endocrinology and Metabolism
Torben Hansen - Novo Nordisk Foundation
Joel N. Hirschhorn - Boston Children's Hospital
Albert Hofman - Erasmus MC
Mads V. Hollegaard - Statens Serum Institut
David M. Hougaard - Statens Serum Institut
Elina Hyppoenen - Biostat
Hazel M. Inskip - University of Southampton
Aaron Isaacs - Erasmus MC
Torben Jorgensen - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Christina Kanaka-Gantenbein - National and Kapodistrian University of Athens
John P. Kemp - University of Bristol
Wieland Kiess - Univ Leipzig, Dept Womens & Child Hlth, Pediat Res Ctr, Leipzig, Germany
Tuomas O. Kilpelainen - MRC Epidemiology Unit
Norman Klopp - Helmholtz Zentrum München
Bridget A. Knight - University of Exeter
Christopher W. Kuzawa - Northwestern University
George McMahon - University of Bristol
John P. Newnham - University of Western Australia
Harri Niinikoski - University of Turku
Ben A. Oostra - Erasmus MC
Louise Pedersen - University of Copenhagen
Dirkje S. Postma - University Medical Center Groningen
Susan M. Ring - University of Bristol
Fernando Rivadeneira - Erasmus MC
Neil R. Robertson - University of Oxford
Sylvain Sebert - University of Oulu
Olli Simell - University of Turku
Torsten Slowinski - Charité - Universitätsmedizin Berlin
Carla M. T. Tiesler - Helmholtz Zentrum München
Anke Toenjes - College Station Medical Center
Allan Vaag - Rigshospitalet
Jorma S. Viikari - Turku University Hospital
Jacqueline M. Vink - Vrije Universiteit Amsterdam
Nadja Hawwa Vissing - Gentofte Hospital
Nicholas J. Wareham - Addenbrooke's Hospital
Gonneke Willemsen - Vrije Universiteit Amsterdam
Daniel R. Witte - Steno Diabetes Center
Haitao Zhang - Children's Hospital of Philadelphia
Early Growth Genetics EGG
Inga Prokopenko - School of Biosciences
Publication Details: Nature genetics, Vol.45(1), pp.76-U115
Publisher: Springer Nature
Number of pages: 10
Date published: 01/01/2013
Grant note: Netherlands Organization for Scientific Research (NWO: Social Sciences (MaGW) British Heart Foundation German Diabetes Association RK/2008.024 / Netherlands Bioinformatics Centre (NBIC) BioAssist SAF2008-00357 / Spanish Ministry of Science and Innovation; Spanish Government US Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA BIF: Boehringer Ingelheim Fonds; Boehringer Ingelheim University of Western Australia (UWA) Turku University Hospital Turku University Foundation
Identifiers: 99928798702346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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