Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017

Christopher E. Troeger; Brigette F. Blacker; Ibrahim A. Khalil; Stephanie R. M. Zimsen; Samuel B. Albertson; Degu Abate; Jemal Abdela; Tara Ballav Adhikari; Sargis Aghasi Aghayan; Sutapa Agrawal; Alireza Ahmadi; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Ayman Al-Eyadhy; Rajaa M. Al-Raddadi; Fares Alahdab; Kefyalew Addis Alene; Syed Mohamed Aljunid; Nelson Alvis-Guzman; Nahla Hamed Anber; Mina Anjomshoa; Carl Abelardo T. Antonio; Olatunde Aremu; Hagos Tasew Atalay; Suleman Atique; Engi F. Attia; Euripide F. G. A. Avokpaho; Ashish Awasthi; Arefeh Babazadeh; Hamid Badali; Alaa Badawi; Joseph Adel Mattar Banoub; Aleksandra Barac; Quique Bassat; Neeraj Bedi; Abate Bekele Belachew; Derrick A. Bennett; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Ali Bijani; Felix Carvalho; Carlos A. Castaneda-Orjuela; Devasahayam J. Christopher; Lalit Dandona; Rakhi Dandona; Anh Kim Dang; Ahmad Daryani; Meaza Girma Degefa; Feleke Mekonnen Demeke; Meghnath Dhimal; Shirin Djalalinia; David Teye Doku; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Dumessa Edessa; Maysaa El Sayed Zaki; Hamed Fakhim; Eduarda Fernandes; Florian Fischer; Luisa Sorio Flor; Kyle J. Foreman; Teklu Gebrehiwo Gebremichael; Demeke Geremew; Keyghobad Ghadiri; Alessandra C. Goulart; Jingwen Guo; Giang Hai Ha; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Samer Hamidi; Hamid Yimam Hassen; Chi Linh Hoang; Nobuyuki Horita; Mihaela Hostiuc; Seyed Sina Naghibi Irvani; Ravi Prakash Jha; Jost B. Jonas; Amaha Kahsay; Andre Karch; Amir Kasaeian; Tesfaye Dessale Kassa; Adane Teshome Kefale; Yousef Saleh Khader; Ejaz Ahmad Khan; Gulfaraz Khan; Md Nuruzzaman Khan; Young-Ho Khang; Abdullah T. Khoja; Jagdish Khubchandani; Ruth W. Kimokoti; Adnan Kisa; Luke D. Knibbs; Sonali Kochhar; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Barthelemy Kuate Defo; G. Anil Kumar; Dharmesh Kumar Lal; Prabhat Lamichhane; Cheru Tesema Leshargie; Miriam Levi; Shanshan Li; Erlyn Rachelle King Macarayan; Marek Majdan; Varshil Mehta; Addisu Melese; Ziad A. Memish; Desalegn Tadese Mengistu; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; George J. Milne; Branko Milosevic; Erkin M. Mirrakhimov; Babak Moazen; Karzan Abdulmuhsin Mohammad; Shafiu Mohammed; Lorenzo Monasta; Lidia Morawska; Seyyed Meysam Mousavi; Oumer Sada S. Muhammed; Srinivas Murthy; Ghulam Mustafa; Aliya Naheed; Huong Lan Thi Nguyen; Nam Ba Nguyen; Son Hoang Nguyen; Trang Huyen Nguyen; Muhammad Imran Nisar; Molly R. Nixon; Felix Akpojene Ogbo; Andrew T. Olagunju; Tinuke O. Olagunju; Eyal Oren; Justin R. Ortiz; P. A. Mahesh; Smita Pakhale; Shanti Patel; Deepak Paudel; David M. Pigott; Maarten J. Postma; Mostafa Qorbani; Anwar Rafay; Alireza Rafiei; Vafa Rahimi-Movaghar; Rajesh Kumar Rai; Mohammad Sadegh Rezai; Nicholas L. S. Roberts; Luca Ronfani; Salvatore Rubino; Saeed Safari; Saeid Safiri; Zikria Saleem; Evanson Zondani Sambala; Abdallah M. Samy; Milena M. Santric Milicevic; Benn Sartorius; Shahabeddin Sarvi; Miloje Savic; Monika Sawhney; Sonia Saxena; Seyedmojtaba Seyedmousavi; Masood Ali Shaikh; Mehdi Sharif; Aziz Sheikh; Mika Shigematsu; David L. Smith; Ranjani Somayaji; Joan B. Soriano; Chandrashekhar T. Sreeramareddy; Mu'awiyyah Babale Sufiyan; Mohamad-Iani Temsah; Belay Tessema; Mebrahtu Teweldemedhin; Miguel Tortajada-Girbes; Bach Xuan Tran; Khanh Bao Tran; Afewerki Gebremeskel Tsadik; Kingsley Nnanna Ukwaja; Irfan Ullah; Tommi Juhani Vasankari; Stein Emil Vollset; Giang Thu Vu; Fiseha Wadilo Wada; Yasir Waheed; T. Eoin West; Charles Shey Wiysonge; Ebrahim M. Yimer; Naohiro Yonemoto; Zoubida Zaidi; Theo Vos; Stephen S. Lim; Christopher J. L. Murray; Ali H. Mokdad; Simon I. Hay; Robert C. Reiner; GBD 2017 Influenza Collaborators

doi:10.1016/S2213-2600(18)30496-X

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Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017

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Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017

Christopher E. Troeger, Brigette F. Blacker, Ibrahim A. Khalil, Stephanie R. M. Zimsen, Samuel B. Albertson, Degu Abate, Jemal Abdela, Tara Ballav Adhikari, Sargis Aghasi Aghayan, Sutapa Agrawal, …

The lancet respiratory medicine, Vol.7(1), pp.69-89

01/01/2019

DOI: https://doi.org/10.1016/S2213-2600(18)30496-X

PMCID: PMC6302221

PMID: 30553848

Abstract

Critical Care Medicine

General & Internal Medicine

Life Sciences & Biomedicine

Respiratory System

Science & Technology

Background Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000-200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16.4 deaths per 100 000 [95% UI 11.6-21.9]), and the highest rate among all ages was in eastern Europe (5.2 per 100 000 population [95% UI 3.5-7.2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000-22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000-259 851 000). We estimated that 11.5% (95% UI 10.0-12.9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000-73 864 000) episodes and 8 172 000 severe episodes (5 000 000-13 296 000). Interpretation This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed. Copyright (c) 2018 The Author(s). Published by Elsevier Ltd.

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Title: Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017
Creators: Christopher E. Troeger - University of Washington
Brigette F. Blacker - University of Washington
Ibrahim A. Khalil - University of Washington
Stephanie R. M. Zimsen - University of Washington
Samuel B. Albertson - University of Washington
Degu Abate - Haramaya University
Jemal Abdela - Haramaya University
Tara Ballav Adhikari - Ctr Social Sci & Publ Hlth Res Nepal, Nepal Hlth Res Environm, Lalitpur, Nepal
Sargis Aghasi Aghayan - Yerevan State University
Sutapa Agrawal - Publ Hlth Fdn India, Gurugram, India
Alireza Ahmadi - College Station Medical Center
Amani Nidhal Aichour - University Ferhat Abbas of Setif
Ibtihel Aichour - University Ferhat Abbas of Setif
Miloud Taki Eddine Aichour - Supreme Council Of Health
Ayman Al-Eyadhy - King Saud University
Rajaa M. Al-Raddadi - King Abdulaziz University
Fares Alahdab - Mayo Clin, Fdn Med Educ & Res, Evidence Based Practice Ctr, Rochester, MN USA
Kefyalew Addis Alene - University of Gondar
Syed Mohamed Aljunid - Kuwait University
Nelson Alvis-Guzman - University of Cartagena
Nahla Hamed Anber - Mansoura University
Mina Anjomshoa - College Station Medical Center
Carl Abelardo T. Antonio - University of the Philippines Manila
Olatunde Aremu - Birmingham City University
Hagos Tasew Atalay - Aksum University
Suleman Atique - University of Lahore
Engi F. Attia - University of Washington
Euripide F. G. A. Avokpaho - Benin Clin Res Inst, Abomey Calavi, Benin
Ashish Awasthi - Publ Hlth Fdn India, Gurugram, India
Arefeh Babazadeh - Ctr Infect Dis Res, Babol Sar, Iran
Hamid Badali - College Station Medical Center
Alaa Badawi - Publ Hlth Agcy Canada, Publ Hlth Risk Sci Div, Toronto, ON, Canada
Joseph Adel Mattar Banoub - Alexandria University
Aleksandra Barac - Clin Ctr Serbia, Clin Infect & Trop Dis, Belgrade, Serbia
Quique Bassat - Barcelona Inst Global Hlth, Barcelona, Spain
Neeraj Bedi - College Station Medical Center
Abate Bekele Belachew - Mekelle University
Derrick A. Bennett - University of Oxford
Krittika Bhattacharyya - Biostat
Zulfiqar A. Bhutta - University of Toronto
Ali Bijani - College Station Medical Center
Felix Carvalho - Universidade do Porto
Carlos A. Castaneda-Orjuela - Natl Inst Hlth, Colombian Natl Hlth Observ, Bogota, Colombia
Devasahayam J. Christopher - College Station Medical Center
Lalit Dandona - University of Washington
Rakhi Dandona - University of Washington
Anh Kim Dang - Duy Tan University
Ahmad Daryani - College Station Medical Center
Meaza Girma Degefa - Mekelle University
Feleke Mekonnen Demeke - University of Gondar
Meghnath Dhimal - Nepal Hlth Res Council, Hlth Res Sect, Kathmandu, Nepal
Shirin Djalalinia - College Station Medical Center
David Teye Doku - University of Cape Coast
Manisha Dubey - World Food Programme
Eleonora Dubljanin - University of Belgrade
Eyasu Ejeta Duken - Wollega University
Dumessa Edessa - Haramaya University
Maysaa El Sayed Zaki - Mansoura University
Hamed Fakhim - Urmia University
Eduarda Fernandes - Universidade do Porto
Florian Fischer - Bielefeld University
Luisa Sorio Flor - Supreme Council Of Health
Kyle J. Foreman - University of Washington
Teklu Gebrehiwo Gebremichael - Mekelle University
Demeke Geremew - University of Gondar
Keyghobad Ghadiri - College Station Medical Center
Alessandra C. Goulart - University of Sao Paulo
Jingwen Guo - University of Washington
Giang Hai Ha - Duy Tan University
Gessessew Bugssa Hailu - Mekelle University
Arvin Haj-Mirzaian - University of Tehran
Arya Haj-Mirzaian - University of Tehran
Samer Hamidi - Hamdan Bin Mohammed Smart University
Hamid Yimam Hassen - Mizan Tepi University
Chi Linh Hoang - Trường ĐH Nguyễn Tất Thành
Nobuyuki Horita - Yokohama City University
Mihaela Hostiuc - College Station Medical Center
Seyed Sina Naghibi Irvani - University of Tehran
Ravi Prakash Jha - Banaras Hindu University
Jost B. Jonas - Heidelberg University
Amaha Kahsay - Mekelle University
Andre Karch - Helmholtz Ctr Infect Res, Dept Epidemiol, Braunschweig, Germany
Amir Kasaeian - University of Tehran
Tesfaye Dessale Kassa - Mekelle University
Adane Teshome Kefale - Mizan Tepi University
Yousef Saleh Khader - College Station Medical Center
Ejaz Ahmad Khan - Biostat
Gulfaraz Khan - United Arab Emirates University
Md Nuruzzaman Khan - Supreme Council Of Health
Young-Ho Khang - Seoul Natl Univ, Inst Hlth Policy & Management, Seoul, South Korea
Abdullah T. Khoja - Johns Hopkins University
Jagdish Khubchandani - Ball State University
Ruth W. Kimokoti - Simmons Coll, Dept Nutr, Boston, MA 02115 USA
Adnan Kisa - University of Oslo
Luke D. Knibbs - University of Queensland
Sonali Kochhar - University of Washington
Soewarta Kosen
Parvaiz A. Koul - College Station Medical Center
Ai Koyanagi - San Juan Dios Sanitary Pk, Res & Dev Unit, St Boi De Llobregat, Spain
Barthelemy Kuate Defo - Université de Montréal
G. Anil Kumar - Publ Hlth Fdn India, Gurugram, India
Dharmesh Kumar Lal - Publ Hlth Fdn India, Gurugram, India
Prabhat Lamichhane - Deakin University
Cheru Tesema Leshargie - Debre Markos University
Miriam Levi - Florence
Shanshan Li - Monash University
Erlyn Rachelle King Macarayan - University of the Philippines Manila
Marek Majdan - Trnava Univ, Dept Publ Hlth, Trnava, Slovakia
Varshil Mehta - College Station Medical Center
Addisu Melese - Debre Tabor University
Ziad A. Memish - Minist Hlth, Prince Mohammed Bin Abdulaziz Hosp, Res Dept, Riyadh, Saudi Arabia
Desalegn Tadese Mengistu - Mekelle University
Tuomo J. Meretoja - Helsinki Univ Hosp, Breast Surg Unit, Helsinki, Finland
Tomislav Mestrovic - Dr Zora Profoz Polyclin, Clin Microbiol & Parasitol Unit, Zagreb, Croatia
Bartosz Miazgowski - College Station Medical Center
George J. Milne - University of Western Australia
Branko Milosevic - Clin Ctr Serbia, Belgrade, Serbia
Erkin M. Mirrakhimov - College Station Medical Center
Babak Moazen - Heidelberg Univ, Inst Publ Hlth, Mannheim, Germany
Karzan Abdulmuhsin Mohammad - Salahaddin Univ, Dept Biol, Erbil, Iraq
Shafiu Mohammed - Heidelberg Univ, Inst Publ Hlth, Mannheim, Germany
Lorenzo Monasta - Burlo Garofolo Inst Maternal & Child Hlth, Clin Epidemiol & Publ Hlth Res Unit, Trieste, Italy
Lidia Morawska - Queensland University of Technology
Seyyed Meysam Mousavi - University of Tehran
Oumer Sada S. Muhammed - Univ Addis Ababa, Pharmacol & Clin Pharm, Addis Ababa, Ethiopia
Srinivas Murthy - University of British Columbia
Ghulam Mustafa - College Station Medical Center
Aliya Naheed - Int Ctr Diarrhoeal Dis Res, Initiat Non Communicable Dis, Dhaka, Bangladesh
Huong Lan Thi Nguyen - Duy Tan University
Nam Ba Nguyen - Trường ĐH Nguyễn Tất Thành
Son Hoang Nguyen - Trường ĐH Nguyễn Tất Thành
Trang Huyen Nguyen - Trường ĐH Nguyễn Tất Thành
Muhammad Imran Nisar - Aga Khan Univ, Dept Pediat & Child Hlth, Karachi, Pakistan
Molly R. Nixon - University of Washington
Felix Akpojene Ogbo - Western Sydney University
Andrew T. Olagunju - University of Adelaide
Tinuke O. Olagunju - McMaster University
Eyal Oren - University of Washington
Justin R. Ortiz - University of Washington
P. A. Mahesh
Smita Pakhale - College Station Medical Center
Shanti Patel - College Station Medical Center
Deepak Paudel - Save Children, Hlth Nutr & HIV AIDS Program, Kathmandu, Nepal
David M. Pigott - University of Washington
Maarten J. Postma - University of Groningen
Mostafa Qorbani - College Station Medical Center
Anwar Rafay - Contech
Alireza Rafiei - College Station Medical Center
Vafa Rahimi-Movaghar - University of Tehran
Rajesh Kumar Rai - Soc Hlth & Demog Surveillance, Suri, India
Mohammad Sadegh Rezai - College Station Medical Center
Nicholas L. S. Roberts - University of Washington
Luca Ronfani - Burlo Garofolo Inst Maternal & Child Hlth, Clin Epidemiol & Publ Hlth Res Unit, Trieste, Italy
Salvatore Rubino - University of Sassari
Saeed Safari - Shahid Beheshti University
Saeid Safiri - College Station Medical Center
Zikria Saleem - University of the Punjab
Evanson Zondani Sambala - South African Med Res Council, Cochrane South Africa, Cape Town, South Africa
Abdallah M. Samy - Ain Shams University
Milena M. Santric Milicevic - University of Belgrade
Benn Sartorius - University of KwaZulu-Natal
Shahabeddin Sarvi - College Station Medical Center
Miloje Savic - GSK Biol, Wavre, Belgium
Monika Sawhney - Univ N Carolina, Dept Publ Hlth Sci, Charlotte, NC USA
Sonia Saxena - Supreme Council Of Health
Seyedmojtaba Seyedmousavi - University of Tehran
Masood Ali Shaikh
Mehdi Sharif - Islamic Azad University
Aziz Sheikh - Harvard University
Mika Shigematsu - Natl Inst Infect Dis, Tokyo, Japan
David L. Smith - University of Washington
Ranjani Somayaji - University of Washington
Joan B. Soriano - Univ Hosp Princesa, Serv Pulmonol, Hlth Res Inst, Madrid, Spain
Chandrashekhar T. Sreeramareddy - College Station Medical Center
Mu'awiyyah Babale Sufiyan - Ahmadu Bello University
Mohamad-Iani Temsah - King Saud University
Belay Tessema - University of Gondar
Mebrahtu Teweldemedhin - Aksum University
Miguel Tortajada-Girbes - Univ Hosp Doctor Peset, Pediat Dept, Valencia, Spain
Bach Xuan Tran - College Station Medical Center
Khanh Bao Tran - University of Auckland
Afewerki Gebremeskel Tsadik - Mekelle University
Kingsley Nnanna Ukwaja - Fed Teaching Hosp, Dept Internal Med, Abakaliki, Nigeria
Irfan Ullah - Gomal Univ, Gomal Ctr Biochem & Biotechnol, Dera Ismail Khan, Pakistan
Tommi Juhani Vasankari - UKK Inst, Tampere, Finland
Stein Emil Vollset - University of Washington
Giang Thu Vu - Trường ĐH Nguyễn Tất Thành
Fiseha Wadilo Wada - Univ Addis Ababa, Dept Microbial Cellular & Mol Biol, Addis Ababa, Ethiopia
Yasir Waheed - College Station Medical Center
T. Eoin West - University of Washington
Charles Shey Wiysonge - Med Res Council South Africa, Cochrane South Africa, Cape Town, South Africa
Ebrahim M. Yimer - Mekelle University
Naohiro Yonemoto - Natl Ctr Neurol & Psychiat, Dept Psychopharmacol, Tokyo, Japan
Zoubida Zaidi - Univ Hosp Setif, Dept Epidemiol, Setif, Algeria
Theo Vos - University of Washington
Stephen S. Lim - University of Washington
Christopher J. L. Murray - University of Washington
Ali H. Mokdad - University of Washington
Simon I. Hay - University of Washington
Robert C. Reiner - University of Washington
GBD 2017 Influenza Collaborators
Publication Details: The lancet respiratory medicine, Vol.7(1), pp.69-89
Publisher: Elsevier
Number of pages: 21
Date published: 01/01/2019
Grant note: Bill AMP; Melinda Gates Foundation; CGIAR
Identifiers: 99777875202346
Academic Unit: School of Sustainability, Civil and Environmental Engineering
Language: English
Resource Type: Journal article

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017

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