Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

AS de Carvalho; K Salomao; SL de Castro; TR Conde; HP da Silva Zamith; ER Caffarena; BS Hall; SR Wilkinson; N Boechat

doi:10.1590/0074-0276140497

Journal article

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

AS de Carvalho, K Salomao, SL de Castro, TR Conde, HP da Silva Zamith, ER Caffarena, BS Hall, SR Wilkinson and N Boechat

MEMORIAS DO INSTITUTO OSWALDO CRUZ, Vol.109(3), pp.315-323

01/05/2014

DOI: https://doi.org/10.1590/0074-0276140497

Abstract

Science & Technology

Life Sciences & Biomedicine

Parasitology

Tropical Medicine

PARASITOLOGY

TROPICAL MEDICINE

megazol

Trypanosoma cruzi

Trypanosoma brucei

T. brucei nitroreductase

genotoxicity

1

3

4-THIADIAZOLE-2-ARYLHYDRAZONE DERIVATIVES

CHAGAS-DISEASE

AMERICAN TRYPANOSOMIASIS

SCORING FUNCTION

COMET ASSAY

DNA-DAMAGE

CRUZI

PROTEIN

AGENTS

MODEL

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Title: Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
Creators: AS de Carvalho
K Salomao
SL de Castro
TR Conde
HP da Silva Zamith
ER Caffarena
BS Hall
SR Wilkinson
N Boechat
Publication Details: MEMORIAS DO INSTITUTO OSWALDO CRUZ, Vol.109(3), pp.315-323
Publisher: FUNDACO OSWALDO CRUZ
Date published: 01/05/2014
Date submitted: 17/05/2017
Identifiers: 99513418402346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

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