Long-term exposure to fine particle elemental components and natural and cause-specific mortality a pooled analysis of eight european cohorts within the ELAPSE project

Jie Chen; Sophia Rodopoulou; Kees de Hoogh; Maciej Strak; Zorana J Andersen; Richard Atkinson; Mariska Bauwelinck; Tom Bellander; Jørgen Brandt; Giulia Cesaroni; Hans Concin; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara Hoffmann; Ulla Arthur Hvidtfeldt; Nicole A H Janssen; Karl-Heinz Jöckel; Jeanette Jørgensen; Klea Katsouyanni; Matthias Ketzel; Jochem O Klompmaker; Anton Lager; Karin Leander; Shuo Liu; Petter Ljungman; Conor J MacDonald; Patrik K E Magnusson; Amar Mehta; Gabriele Nagel; Bente Oftedal; Göran Pershagen; Annette Peters; Ole Raaschou-Nielsen; Matteo Renzi; Debora Rizzuto; Evangelia Samoli; Yvonne T van der Schouw; Sara Schramm; Per Schwarze; Torben Sigsgaard; Mette Sørensen; Massimo Stafoggia; Anne Tjønneland; Danielle Vienneau; Gudrun Weinmayr; Kathrin Wolf; Bert Brunekreef; Gerard Hoek

doi:10.1289/EHP8368

Back

Long-term exposure to fine particle elemental components and natural and cause-specific mortality a pooled analysis of eight european cohorts within the ELAPSE project

Journal article

Open access

Peer reviewed

Long-term exposure to fine particle elemental components and natural and cause-specific mortality a pooled analysis of eight european cohorts within the ELAPSE project

Jie Chen, Sophia Rodopoulou, Kees de Hoogh, Maciej Strak, Zorana J Andersen, Richard Atkinson, Mariska Bauwelinck, Tom Bellander, Jørgen Brandt, Giulia Cesaroni, …

Environmental health perspectives, Vol.129(4), pp.047009-1-047009-12

12/04/2021

DOI: https://doi.org/10.1289/EHP8368

PMID: 33844598

Abstract

Background: Inconsistent associations between long-term exposure to particles with an aerodynamic diameter ≤2.5 μm [fine particulate matter (PM2.5)] components and mortality have been reported, partly related to challenges in exposure assessment. Objectives: We investigated the associations between long-term exposure to PM2.5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2.5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms. Methods: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985–2005). Residential exposure to 2010 annual average concentration of eight PM2.5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100×100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2.5 mass and nitrogen dioxide (NO2) separately. Results: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2.5 and NO2. HRs only remained (almost) significant for RF-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR- and RF-modeled exposures, respectively, per 2 ng/m3, adjusting for PM2.5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models. Conclusion: Long-term exposure to V in PM2.5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RF than SLR in two-pollutant models. https://doi.org/10.1289/EHP8368

Files and links (1)

url

https://doi.org/10.1289/EHP8368View

Published (Version of record) Open

Metrics

47 Record Views

55 Times Cited - Web of Science

See more details

Details

Title: Long-term exposure to fine particle elemental components and natural and cause-specific mortality a pooled analysis of eight european cohorts within the ELAPSE project
Creators: Jie Chen - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Sophia Rodopoulou - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Kees de Hoogh - University of Basel, Basel, Switzerland
Maciej Strak - National Institute for Public Health and the Environment, Bilthoven, Netherlands
Zorana J Andersen - Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Richard Atkinson - Population Health Research, St George's, University of London, London, UK
Mariska Bauwelinck - Interface Demography, Department of Sociology, Vrije Universiteit Brussel, Brussels, Belgium
Tom Bellander - Centre for Occupational and Environmental Medicine, Stockholm, Sweden
Jørgen Brandt - Department of Environmental Science, Aarhus University, Denmark
Giulia Cesaroni - Department of Epidemiology, Lazio Region Health Service, Rome, Italy
Hans Concin - Agency for Preventive and Social Medicine, Bregenz, Austria
Daniela Fecht - Medical Research Council Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
Francesco Forastiere - Science Policy and Epidemiology Environmental Research Group, King's College London, London, UK
John Gulliver - Centre for Environmental Health and Sustainability, School of Geography, Geology and the Environment, University of Leicester, Leicester, UK
Ole Hertel - Department of Environmental Science, Aarhus University, Denmark
Barbara Hoffmann - Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Medical Faculty, Heinrich Heine University Düsseldorf, Germany
Ulla Arthur Hvidtfeldt - Danish Cancer Society Research Center, Copenhagen, Denmark
Nicole A H Janssen - National Institute for Public Health and the Environment, Bilthoven, Netherlands
Karl-Heinz Jöckel - Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany
Jeanette Jørgensen - Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Klea Katsouyanni - Science Policy and Epidemiology Environmental Research Group, King's College London, London, UK
Matthias Ketzel - Global Centre for Clean Air Research, University of Surrey, Guildford, UK
Jochem O Klompmaker - Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Anton Lager - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden
Karin Leander - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Shuo Liu - Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Petter Ljungman - Department of Cardiology, Danderyd University Hospital, Stockholm, Sweden
Conor J MacDonald - Department of Statistics, Computer Science and Applications, University of Florence, Florence, Italy
Patrik K E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Amar Mehta - Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Gabriele Nagel - Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
Bente Oftedal - Department of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Göran Pershagen - Centre for Occupational and Environmental Medicine, Stockholm, Sweden
Annette Peters - Department of Epidemiology, Ludwig Maximilians Universität München, Munich, Germany
Ole Raaschou-Nielsen - Danish Cancer Society Research Center, Copenhagen, Denmark
Matteo Renzi - Department of Epidemiology, Lazio Region Health Service, Rome, Italy
Debora Rizzuto - Stockholm Gerontology Research Center, Stockholm, Sweden
Evangelia Samoli - Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
Yvonne T van der Schouw - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Sara Schramm - Institute for Medical Informatics, Biometry and Epidemiology, Medical Faculty, University of Duisburg-Essen, Essen, Germany
Per Schwarze - Department of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
Torben Sigsgaard - Department of Public Health, Section of Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
Mette Sørensen - Danish Cancer Society Research Center, Copenhagen, Denmark
Massimo Stafoggia - Department of Epidemiology, Lazio Region Health Service, Rome, Italy
Anne Tjønneland - Danish Cancer Society Research Center, Copenhagen, Denmark
Danielle Vienneau - University of Basel, Basel, Switzerland
Gudrun Weinmayr - Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
Kathrin Wolf - Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
Bert Brunekreef - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Gerard Hoek - Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
Publication Details: Environmental health perspectives, Vol.129(4), pp.047009-1-047009-12
Publisher: United States
Date published: 12/04/2021
Date accepted: 15/03/2021
Identifiers: 99552423702346
Copyright: Reproduced with permission from Environmental Health Perspectives.
Academic Unit: School of Sustainability, Civil and Environmental Engineering
Language: English
Resource Type: Journal article
SDG (Scopus 2023): SDG 3

Long-term exposure to fine particle elemental components and natural and cause-specific mortality a pooled analysis of eight european cohorts within the ELAPSE project

Abstract

Files and links (1)

Metrics

Details

Usage Policy