Lithiated porous silicon nanowires stimulate periodontal regeneration

Martti Kaasalainen; Ran Zhang; Priya Vashisth; Anahid Ahmadi Birjandi; Mark S'Ari; Davide Martella; Mark Isaacs; Ermei Mäkilä; Cong Wang; Evelin Moldenhauer; Paul Clarke; Alessandra Pinna; Xuechen Zhang; Salman A Mustfa; Valeria Caprettini; Alexander P Morrell; Eileen Gentleman; Delia S Brauer; Owen Addison; Xuehui Zhang; Mads Bergholt; Khuloud Al-Jamal; Ana Angelova Volponi; Jarno Salonen; Nicole Hondow; Paul Sharpe; Ciro Chiappini

doi:10.1038/s41467-023-44581-5

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Lithiated porous silicon nanowires stimulate periodontal regeneration

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Lithiated porous silicon nanowires stimulate periodontal regeneration

Martti Kaasalainen, Ran Zhang, Priya Vashisth, Anahid Ahmadi Birjandi, Mark S'Ari, Davide Martella, Mark Isaacs, Ermei Mäkilä, Cong Wang, Evelin Moldenhauer, …

Nature communications, Vol.15(1), 487

12/01/2024

DOI: https://doi.org/10.1038/s41467-023-44581-5

PMID: 38216556

Abstract

Animals

beta Catenin

Dental Cementum

Lithium - pharmacology

Mice

Nanowires

Porosity

Silicic Acid - pharmacology

Silicon - pharmacology

Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.

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Title: Lithiated porous silicon nanowires stimulate periodontal regeneration
Creators: Martti Kaasalainen - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Ran Zhang - Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, 100081, PR China
Priya Vashisth - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Anahid Ahmadi Birjandi - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Mark S'Ari - School of Chemical and Process Engineering, University of Leeds, Leeds, LS2 9JT, UK
Davide Martella - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Mark Isaacs - HarwellXPS, Research Complex at Harwell, Rutherford Appleton Labs, Didcot, OX11 0DE, UK
Ermei Mäkilä - Department of Physics and Astronomy, University of Turku, Turku, 20014, Finland
Cong Wang - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Evelin Moldenhauer - Postnova Analytics GmbH, Rankinestr. 1, Landsberg am Lech, 86899, Germany
Paul Clarke - Postnova Analytics GmbH, Rankinestr. 1, Landsberg am Lech, 86899, Germany
Alessandra Pinna - University of Surrey, School of Veterinary Medicine
Xuechen Zhang - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Salman A Mustfa - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Valeria Caprettini - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Alexander P Morrell - Centre for Oral Clinical & Translational Sciences, King's College London, London, SE1 9RT, UK
Eileen Gentleman - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Delia S Brauer - Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Jena, 07743, Germany
Owen Addison - Centre for Oral Clinical & Translational Sciences, King's College London, London, SE1 9RT, UK
Xuehui Zhang - Department of Dental Materials & NMPA Key Laboratory for Dental Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, PR China
Mads Bergholt - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Khuloud Al-Jamal - Institute of Pharmaceutical Science, King's College London, London, SE1 9NH, UK
Ana Angelova Volponi - Centre for Craniofacial and Regenerative Biology, King's College London, London, SE1 9RT, UK
Jarno Salonen - Department of Physics and Astronomy, University of Turku, Turku, 20014, Finland
Nicole Hondow - School of Chemical and Process Engineering, University of Leeds, Leeds, LS2 9JT, UK
Paul Sharpe - Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, 602 00, Czech Republic
Ciro Chiappini - London Centre for Nanotechnology, King's College London, London, WC2R 2LS, UK. ciro.chiappini@kcl.ac.uk
Publication Details: Nature communications, Vol.15(1), 487
Date published: 12/01/2024
Date accepted: 20/12/2023
Grants: MC/PC/18052, Medical Research Council (United Kingdom, London) - MRC
759577, European Research Council (Belgium, Brussels) - ERC
EP/R02863X/1, Engineering and Physical Sciences Research Council (United Kingdom, Swindon) - EPSRC
82270945, National Natural Science Foundation of China (China, Beijing) - NSFC
GACR 21-21409S, Czech Science Foundation (Czechia, Prague) - GAČR
Identifiers: 99855766102346
Academic Unit: School of Veterinary Medicine
Language: English
Resource Type: Journal article

Lithiated porous silicon nanowires stimulate periodontal regeneration

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