Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

M Coulson; GG Gibson; N Plant; T Hammond; M Graham

doi:10.1016/S0041-008X(03)00275-8

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Journal article

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

M Coulson, GG Gibson, N Plant, T Hammond and M Graham

TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol.192(2), pp.154-163

15/10/2003

DOI: https://doi.org/10.1016/S0041-008X(03)00275-8

Abstract

Science & Technology

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Toxicology

PHARMACOLOGY & PHARMACY

TOXICOLOGY

lansoprazole

liver

testis

testosterone metabolism

Leydig cell

hyperplasia

turnouts

cytochrome p450

steroid hydroxylases

induction

rat

FOLLICLE-STIMULATING-HORMONE

BUTYL ETHER MTBE

LUTEINIZING-HORMONE

CYTOCHROME-P-450 ISOZYMES

LIVER MICROSOMES

CD-1 MICE

INDUCTION

EXPRESSION

MECHANISMS

SECRETION

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Title: Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis
Creators: M Coulson
GG Gibson
N Plant
T Hammond
M Graham
Publication Details: TOXICOLOGY AND APPLIED PHARMACOLOGY, Vol.192(2), pp.154-163
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Date published: 15/10/2003
Date submitted: 17/05/2017
Identifiers: 99514449402346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

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