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Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity
Journal article   Peer reviewed

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

J Thirlway, R Lewis, L Nunns, M Al Nakeeb, M Styles, A-W Struck, CP Smith and J Micklefield
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol.51(29), pp.7181-7184
01/01/2012
DOI: https://doi.org/10.1002/anie.201202043

Abstract

Science & Technology Physical Sciences Chemistry Multidisciplinary Chemistry adenylation domain antibiotics biosynthetic engineering natural products nonribosomal peptides DEPENDENT LIPOPEPTIDE ANTIBIOTICS PRECURSOR-DIRECTED BIOSYNTHESIS STREPTOMYCES-COELICOLOR TRYPTOPHAN DEHYDROGENATION (2S 3R)-3-METHYL GLUTAMATE CONFERRING CODE IN-VIVO DAPTOMYCIN SYNTHETASES DERIVATIVES
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