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Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells
Journal article   Open access  Peer reviewed

Inflammatory cytokines inhibit Kaposi's sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells

Steven Milligan, Mairi Robinson, Elizabeth O'Donnell and David J Blackbourn
Journal of virology, Vol.78(5), pp.2591-2596
03/2004
DOI: https://doi.org/10.1128/JVI.78.5.2591-2596.2004
PMCID: PMC369204
PMID: 14963163

Abstract

Cell Line Herpesvirus 8, Human - drug effects Transcription, Genetic - drug effects Gene Expression Regulation, Viral - drug effects Humans Herpesvirus 8, Human - genetics Open Reading Frames - genetics Promoter Regions, Genetic - genetics Inflammation - metabolism Inflammation Mediators - pharmacology Endothelial Cells - virology Cytokines - pharmacology Herpesvirus 8, Human - physiology Endothelial Cells - drug effects
The response of Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) to inflammatory cytokine treatment of experimentally infected endothelial cells was investigated. The cytokines inhibited spontaneous KSHV lytic gene expression but not the level of infection. The data suggest that if inflammatory cytokines present in KS lesions contribute to KSHV pathogenesis, they do so in part by promoting latent KSHV infection of the endothelial cells.
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https://doi.org/10.1128/JVI.78.5.2591-2596.2004View
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