Abstract
Social anxiety disorder (SAD) runs in families. Neurobiological alterations have been reported, including changes in functional connectivity (FC); such network changes are, for example, reflective of atypical attentional processes. It is still unknown whether these changes are genetically linked with the disorder and qualify as candidate endophenotypes of SAD. We used data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, and investigated whether social anxiety (SA) co-segregated with changes in intrinsic (i)FC.