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In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.
Journal article   Open access  Peer reviewed

In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues.

Abdelali Agouni, C Owen, A Czopek, N Mody and M Delibegovic
Biochem Biophys Res Commun, Vol.401(1), pp.104-111
08/10/2010
DOI: https://doi.org/10.1016/j.bbrc.2010.09.018

Abstract

Adipose Tissue Animals Blood Glucose Eating Fasting Glycogen Synthase Kinase 3 Insulin Insulin Receptor Substrate Proteins Liver Male Mice Mice Inbred C57BL Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Muscle Skeletal Phosphorylation Proto-Oncogene Proteins c-akt Receptor Insulin Ribosomal Protein S6 Signal Transduction
Components of the insulin receptor signaling pathway are probably some of the best studied ones. Even though methods for studying these components are well established, the in vivo effects of different fasting regimens, and the time course of insulin receptor phosphorylation and that of its downstream components in insulin-sensitive peripheral tissues have not been analyzed in detail.
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http://dx.doi.org/10.1016/j.bbrc.2010.09.018View
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