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In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.
Journal article   Peer reviewed

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.

DJ Stuckey, CA Carr, P Camelliti, DJ Tyler, KE Davies and K Clarke
PLoS One, Vol.7(1), pp.e28569-?
2012
DOI: https://doi.org/10.1371/journal.pone.0028569

Abstract

Animals Disease Models Animal Disease Progression Dobutamine Fibrosis Gadolinium Heart Magnetic Resonance Imaging Male Mice Mice Inbred mdx Muscular Dystrophies Myocardium Stress Physiological Time Factors Ventricular Dysfunction Left Ventricular Dysfunction Right
The mdx mouse has proven to be useful in understanding the cardiomyopathy that frequently occurs in muscular dystrophy patients. Here we employed a comprehensive array of clinically relevant in vivo MRI techniques to identify early markers of cardiac dysfunction and follow disease progression in the hearts of mdx mice.
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http://www.ncbi.nlm.nih.gov/pubmed/22235247View
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