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In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity.
Journal article

In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity.

E Hamza, CA Akdis, B Wagner, F Steinbach and E Marti
Clin Exp Allergy, Vol.43(8), pp.889-901
08/2013
DOI: https://doi.org/10.1111/cea.12131

Abstract

CD4+ CD25+ T cells FoxP3 IBH IL-10 IL-4 Icelandic horses Treg expansion Treg induction Treg suppression allergy rIL-2 and rTGF-β1. retinoic acid and rapamycin Allergens Animals Antigens CD4 Cytokines Epitopes T-Lymphocyte Female Forkhead Transcription Factors Horses Hypersensitivity Immune Tolerance Insect Bites and Stings Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Activation Male T-Lymphocytes Regulatory Transforming Growth Factor beta
Insect bite hypersensitivity (IBH) is a recurrent allergic dermatitis of horses with similarities to human atopic eczema, caused by bites of insects of the genus Culicoides. Previous studies suggested a dysregulated T cell tolerance to Culicoides allergen in IBH-affected horses.
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http://www.ncbi.nlm.nih.gov/pubmed/23889243View
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