Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.

SP Graham; R Saya; E Awino; D Ngugi; JK Nyanjui; R Hecker; EL Taracha; V Nene

doi:10.1016/j.vetimm.2006.11.010

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Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.

Journal article

Peer reviewed

Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.

SP Graham, R Saya, E Awino, D Ngugi, JK Nyanjui, R Hecker, EL Taracha and V Nene

Vet Immunol Immunopathol, Vol.115(3-4), pp.383-389

15/02/2007

DOI: https://doi.org/10.1016/j.vetimm.2006.11.010

Abstract

Adjuvants

Immunologic

Amino Acid Sequence

Animals

Antibodies

Protozoan

Antigens

Protozoan

CD4-Positive T-Lymphocytes

Cattle

Enzyme-Linked Immunosorbent Assay

Flow Cytometry

Immunization

Interferon-gamma

Lymphocyte Activation

Male

Molecular Sequence Data

Oligodeoxyribonucleotides

Protozoan Proteins

Recombinant Fusion Proteins

T-Lymphocytes

Cytotoxic

Theileria parva

Theileriasis

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymorphic immunodominant molecule from Theileria parva emulsified with immunostimulatory CpG oligodeoxynucleotides in adjuvant had no effect on the induction of antibody responses including the isotype profile, but significantly enhanced the induction of cytolytic responses that were mediated by CD4+CD3+ T cells utilizing the perforin-granzyme pathway.

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Title: Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.
Creators: SP Graham
R Saya
E Awino
D Ngugi
JK Nyanjui
R Hecker
EL Taracha
V Nene
Publication Details: Vet Immunol Immunopathol, Vol.115(3-4), pp.383-389
Date published: 15/02/2007
Date submitted: 17/05/2017
Identifiers: 99511208302346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva.

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