Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Mariaelisa Graff; Robert A. Scott; Anne E. Justice; Kristin L. Young; Mary F. Feitosa; Llilda Barata; Thomas W. Winkler; Audrey Y. Chu; Anubha Mahajan; David Hadley; Luting Xue; Tsegaselassie Workalemahu; Nancy L. Heard-Costa; Marcel den Hoed; Tarunveer S. Ahluwalia; Qibin Qi; Julius S. Ngwa; Frida Renstrom; Lydia Quaye; John D. Eicher; James E. Hayes; Marilyn Cornelis; Zoltan Kutalik; Elise Lim; Jian'an Luan; Jennifer E. Huffman; Weihua Zhang; Wei Zhao; Paula J. Griffin; Toomas Haller; Shafqat Ahmad; Pedro M. Marques-Vidal; Stephanie Bien; Loic Yengo; Alexander Teumer; Albert Vernon Smith; Meena Kumari; Marie Neergaard Harder; Johanne Marie Justesen; Marcus E. Kleber; Mette Hollensted; Kurt Lohman; Natalia V. Rivera; John B. Whitfield; Jing Hua Zhao; Heather M. Stringham; Leo-Pekka Lyytikainen; Charlotte Huppertz; Gonneke Willemsen; Wouter J. Peyrot; Ying Wu; Kati Kristiansson; Ayse Demirkan; Myriam Fornage; Maija Hassinen; Lawrence F. Bielak; Gemma Cadby; Toshiko Tanaka; Reedlk Magl; Peter J. Van der Most; Anne U. Jackson; Jennifer L. Bragg-Gresham; Veronique Vitart; Jonathan Marten; Pau Navarro; Claire Bellis; Dorota Pasko; Asa Johansson; Soren Snitker; Yu-Ching Cheng; Joel Eriksson; Unhee Lim; Mette Aadahl; Linda S. Adair; Najaf Amin; Beverley Balkau; Juha Auvinen; John Beilby; Richard N. Bergman; Sven Bergmann; Alain G. Bertoni; John Blangero; Amelle Bonnefond; Lori L. Bonnycastle; Judith B. Borja; Soren Brage; Fabio Busonero; Steve Buyske; Harry Campbell; Peter S. Chines; Francis S. Collins; Tanguy Corre; George Davey Smith; Graciela E. Delgado; Nicole Dueker; Marcus Doerr; Tapani Ebeling; Gudny Eiriksdottir; Tonu Esko; Jessica D. Faul; PAGE Consortium; Inga Prokopenko

doi:10.1371/journal.pgen.1006528

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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, …

PLoS genetics, Vol.13(4), pp.e1006528-e1006528

27/04/2017

DOI: https://doi.org/10.1371/journal.pgen.1006528

PMID: 28448500

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

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Title: Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Creators: Mariaelisa Graff - University of North Carolina at Chapel Hill
Robert A. Scott - University of Cambridge
Anne E. Justice - University of North Carolina at Chapel Hill
Kristin L. Young - University of North Carolina at Chapel Hill
Mary F. Feitosa - Washington University in St. Louis
Llilda Barata - Washington University in St. Louis
Thomas W. Winkler - University of Regensburg
Audrey Y. Chu - Brigham and Women's Hospital
Anubha Mahajan - University of Oxford
David Hadley - St George's, University of London
Luting Xue - Framingham Heart Study
Tsegaselassie Workalemahu - Harvard University
Nancy L. Heard-Costa - Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA
Marcel den Hoed - University of Cambridge
Tarunveer S. Ahluwalia - University of Copenhagen
Qibin Qi - Albert Einstein College of Medicine
Julius S. Ngwa - Howard University
Frida Renstrom - Umeå University
Lydia Quaye - King's College London
John D. Eicher - Framingham Heart Study
James E. Hayes - Cornell University
Marilyn Cornelis - Harvard University
Zoltan Kutalik - SIB Swiss Institute of Bioinformatics
Elise Lim - Boston University
Jian'an Luan - University of Cambridge
Jennifer E. Huffman - University of Edinburgh
Weihua Zhang - Imperial College London
Wei Zhao - Michigan United
Paula J. Griffin - Boston University
Toomas Haller - University of Tartu
Shafqat Ahmad - Lund University
Pedro M. Marques-Vidal - College Station Medical Center
Stephanie Bien - Fred Hutch Cancer Center
Loic Yengo - Université de Lille
Alexander Teumer - German Centre for Cardiovascular Research
Albert Vernon Smith - Icelandic Heart Association
Meena Kumari - University of Essex
Marie Neergaard Harder - Novo Nordisk Foundation
Johanne Marie Justesen - Novo Nordisk Foundation
Marcus E. Kleber - University Hospital Heidelberg
Mette Hollensted - University of Copenhagen
Kurt Lohman - Wake Forest University
Natalia V. Rivera - Karolinska Institutet
John B. Whitfield - QIMR Berghofer Medical Research Institute
Jing Hua Zhao - University of Cambridge
Heather M. Stringham - University of Michigan–Ann Arbor
Leo-Pekka Lyytikainen - Fimlab
Charlotte Huppertz - Vrije Universiteit Amsterdam
Gonneke Willemsen - Vrije Universiteit Amsterdam
Wouter J. Peyrot - GGZ inGeest
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Kati Kristiansson - Finnish Institute for Health and Welfare
Ayse Demirkan - Leiden University Medical Center
Myriam Fornage - The University of Texas Health Science Center at Houston
Maija Hassinen - University of Eastern Finland
Lawrence F. Bielak - University of Michigan–Ann Arbor
Gemma Cadby - University of Western Australia
Toshiko Tanaka - National Institute on Aging
Reedlk Magl - University of Tartu
Peter J. Van der Most - University Medical Center Groningen
Anne U. Jackson - University of Michigan–Ann Arbor
Jennifer L. Bragg-Gresham - Biostat
Veronique Vitart - University of Edinburgh
Jonathan Marten - MRC Institute of Genetics and Molecular Medicine
Pau Navarro - MRC Institute of Genetics and Molecular Medicine
Claire Bellis - Queensland University of Technology
Dorota Pasko - University of Exeter
Asa Johansson - Uppsala University
Soren Snitker - Supreme Council Of Health
Yu-Ching Cheng - Supreme Council Of Health
Joel Eriksson - University of Gothenburg
Unhee Lim - University of Hawaiʻi at Mānoa
Mette Aadahl - University of Copenhagen
Linda S. Adair - University of North Carolina at Chapel Hill
Najaf Amin - Erasmus MC
Beverley Balkau - Centre de recherche en Epidémiologie et Santé des Populations
Juha Auvinen - Oulu University Hospital
John Beilby - Sir Charles Gairdner Hospital
Richard N. Bergman - Cedars-Sinai Medical Center
Sven Bergmann - SIB Swiss Institute of Bioinformatics
Alain G. Bertoni - Wake Forest University
John Blangero - Texas Biomedical Research Institute
Amelle Bonnefond - Université de Lille
Lori L. Bonnycastle - National Human Genome Research Institute
Judith B. Borja - University of San Carlos
Soren Brage - University of Cambridge
Fabio Busonero - Institute of Genetic and Biomedical Research
Steve Buyske - Rutgers State Univ, Dept Genet, Piscataway, NJ USA
Harry Campbell - Centre for Global Health Research
Peter S. Chines - National Human Genome Research Institute
Francis S. Collins - National Human Genome Research Institute
Tanguy Corre - SIB Swiss Institute of Bioinformatics
George Davey Smith - University of Bristol
Graciela E. Delgado - University Medical Centre Mannheim
Nicole Dueker - University of Maryland, Baltimore
Marcus Doerr - DZHK, German Ctr Cardiovasc Res, Greifswald, Germany
Tapani Ebeling - University of Oulu
Gudny Eiriksdottir - Iceland Heart Assoc, Kopavogur, Iceland
Tonu Esko - University of Tartu
Jessica D. Faul - University of Michigan–Ann Arbor
PAGE Consortium
Inga Prokopenko - School of Biosciences
Publication Details: PLoS genetics, Vol.13(4), pp.e1006528-e1006528
Publisher: Public Library Science
Number of pages: 26
Date published: 27/04/2017
Grant note: Genetic Association Information Network of the Foundation for the National Institutes of Health RP-PG 0407 -10371 / UK National Institute for Health Research; National Institutes of Health Research (NIHR) ALK-Abello' NS (Horsholm, Denmark) CZD/16/6 / Scottish Executive Health Department Dutch Ministry of Justice German Diabetes Association Federation Francaise de Cardiologie Research Centre for Prevention and Health, the Capital Region for Denmark Center for Medical Systems Biology Vastra Gotaland Foundation
Identifiers: 99928686802346
Academic Unit: School of Biosciences; Institute for Sustainability; Surrey Institute for People-Centred AI
Language: English
Resource Type: Journal article

Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

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