Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Nicola Barban; Rick Jansen; Ronald de Vlaming; Ahmad Vaez; Jornt J Mandemakers; Felix C Tropf; Xia Shen; James F Wilson; Daniel I Chasman; Ilja M Nolte; Vinicius Tragante; Sander W van der Laan; John R B Perry; Augustine Kong; Tarunveer S Ahluwalia; Eva Albrecht; Laura Yerges-Armstrong; Gil Atzmon; Kirsi Auro; Kristin Ayers; Andrew Bakshi; Danny Ben-Avraham; Klaus Berger; Aviv Bergman; Lars Bertram; Lawrence F Bielak; Gyda Bjornsdottir; Marc Jan Bonder; Linda Broer; Minh Bui; Caterina Barbieri; Alana Cavadino; Jorge E Chavarro; Constance Turman; Maria Pina Concas; Heather J Cordell; Gail Davies; Peter Eibich; Nicholas Eriksson; Tõnu Esko; Joel Eriksson; Fahimeh Falahi; Janine F Felix; Mark Alan Fontana; Lude Franke; Ilaria Gandin; Audrey J Gaskins; Christian Gieger; Erica P Gunderson; Xiuqing Guo; Caroline Hayward; Chunyan He; Edith Hofer; Hongyan Huang; Peter K Joshi; Stavroula Kanoni; Robert Karlsson; Stefan Kiechl; Annette Kifley; Alexander Kluttig; Peter Kraft; Vasiliki Lagou; Cecile Lecoeur; Jari Lahti; Ruifang Li-Gao; Penelope A Lind; Tian Liu; Enes Makalic; Crysovalanto Mamasoula; Lindsay Matteson; Hamdi Mbarek; Patrick F McArdle; George McMahon; S Fleur W Meddens; Evelin Mihailov; Mike Miller; Stacey A Missmer; Claire Monnereau; Peter J van der Most; Ronny Myhre; Mike A Nalls; Teresa Nutile; Ioanna Panagiota Kalafati; Eleonora Porcu; Inga Prokopenko; Kumar B Rajan; Janet Rich-Edwards; Cornelius A Rietveld; Antonietta Robino; Lynda M Rose; Rico Rueedi; Kathleen A Ryan; Yasaman Saba; Daniel Schmidt; Jennifer A Smith; Lisette Stolk; Elizabeth Streeten; Anke Tönjes; Gudmar Thorleifsson; Sheila Ulivi; LifeLines Cohort Study

doi:10.1038/ng.3698

Back

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Journal article

Peer reviewed

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Nicola Barban, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, …

Nature genetics, Vol.48(12), pp.1462-1472

01/12/2016

DOI: https://doi.org/10.1038/ng.3698

PMID: 27798627

Abstract

Birth Order

Female

Fertility - genetics

Genome-Wide Association Study

Humans

Maternal Age

Parity - genetics

Phenotype

Polymorphism, Single Nucleotide - genetics

Pregnancy

Quantitative Trait Loci

Reproduction - genetics

Reproductive Behavior - physiology

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

Metrics

1 Record Views

See more details

Details

Title: Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Creators: Nicola Barban - University of Oxford
Rick Jansen - Amsterdam UMC Location VUmc
Ronald de Vlaming - Erasmus University Rotterdam
Ahmad Vaez - University Medical Center Groningen
Jornt J Mandemakers - Wageningen University & Research
Felix C Tropf - University of Oxford
Xia Shen - Karolinska Institutet
James F Wilson - MRC Institute of Genetics and Molecular Medicine
Daniel I Chasman - Harvard University
Ilja M Nolte - University Medical Center Groningen
Vinicius Tragante - University Medical Center Utrecht
Sander W van der Laan - University Medical Center Utrecht
John R B Perry - University of Cambridge
Augustine Kong - University of Iceland
Tarunveer S Ahluwalia - University of Copenhagen
Eva Albrecht - Helmholtz Zentrum München
Laura Yerges-Armstrong - University of Maryland, Baltimore
Gil Atzmon - Albert Einstein College of Medicine
Kirsi Auro - Finnish Institute for Health and Welfare
Kristin Ayers - Newcastle University
Andrew Bakshi - University of Queensland
Danny Ben-Avraham - Albert Einstein College of Medicine
Klaus Berger - University of Münster
Aviv Bergman - Albert Einstein College of Medicine
Lars Bertram - Institute for Integrative and Experimental Genomics
Lawrence F Bielak - University of Michigan–Ann Arbor
Gyda Bjornsdottir - deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
Marc Jan Bonder - University of Groningen
Linda Broer - Erasmus MC
Minh Bui - University of Melbourne
Caterina Barbieri - San Raffaele University of Rome
Alana Cavadino - University College London
Jorge E Chavarro - Harvard University
Constance Turman - Harvard University
Maria Pina Concas - Institute of Genetic and Biomedical Research
Heather J Cordell - Newcastle University
Gail Davies - University of Edinburgh
Peter Eibich - University of Oxford
Nicholas Eriksson - 23andMe
Tõnu Esko - University of Tartu
Joel Eriksson - University of Gothenburg
Fahimeh Falahi - University Medical Center Groningen
Janine F Felix - Erasmus MC
Mark Alan Fontana - University of Southern California
Lude Franke - University of Groningen
Ilaria Gandin - University of Trieste
Audrey J Gaskins - Harvard University
Christian Gieger - Helmholtz Zentrum München
Erica P Gunderson - Kaiser Permanente
Xiuqing Guo - The Lundquist Institute
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Chunyan He - Indiana University – Purdue University Indianapolis
Edith Hofer - Medical University of Graz
Hongyan Huang - Harvard University
Peter K Joshi - University of Edinburgh
Stavroula Kanoni - Queen Mary University of London
Robert Karlsson - Karolinska Institutet
Stefan Kiechl - Innsbruck Medical University
Annette Kifley - Westmead Institute for Medical Research
Alexander Kluttig - Martin Luther University Halle-Wittenberg
Peter Kraft - Harvard University
Vasiliki Lagou - KU Leuven
Cecile Lecoeur - Université de Lille
Jari Lahti - University of Helsinki
Ruifang Li-Gao - Leiden University Medical Center
Penelope A Lind - QIMR Berghofer Medical Research Institute
Tian Liu - Max Planck Institute for Human Development
Enes Makalic - University of Melbourne
Crysovalanto Mamasoula - Newcastle University
Lindsay Matteson - University of Minnesota
Hamdi Mbarek - EMGO Institute for Health and Care Research
Patrick F McArdle - University of Maryland, Baltimore
George McMahon - University of Bristol
S Fleur W Meddens - Erasmus University Rotterdam
Evelin Mihailov - University of Tartu
Mike Miller - University of Minnesota
Stacey A Missmer - Harvard University
Claire Monnereau - Erasmus MC
Peter J van der Most - University Medical Center Groningen
Ronny Myhre - Norwegian Institute of Public Health
Mike A Nalls - National Institutes of Health
Teresa Nutile - Institute of Genetics and Biophysics
Ioanna Panagiota Kalafati - Harokopio University of Athens
Eleonora Porcu - Institute of Genetic and Biomedical Research
Inga Prokopenko - Genomics
Kumar B Rajan - Rush University Medical Center
Janet Rich-Edwards - Brigham and Women's Hospital
Cornelius A Rietveld - Erasmus University Rotterdam
Antonietta Robino - IRCCS Materno Infantile Burlo Garofolo
Lynda M Rose - Brigham and Women's Hospital
Rico Rueedi - University of Lausanne
Kathleen A Ryan - University of Maryland, Baltimore
Yasaman Saba - Medical University of Graz
Daniel Schmidt - University of Melbourne
Jennifer A Smith - University of Michigan–Ann Arbor
Lisette Stolk - Erasmus MC
Elizabeth Streeten - University of Maryland, Baltimore
Anke Tönjes - Leipzig University
Gudmar Thorleifsson - deCODE Genetics/Amgen, Inc., Reykjavik, Iceland
Sheila Ulivi - IRCCS Materno Infantile Burlo Garofolo
LifeLines Cohort Study
Publication Details: Nature genetics, Vol.48(12), pp.1462-1472
Date published: 01/12/2016
Grant note: SDR 10-012 / HSRD VA R01 AG051635 / NIA NIH HHS UL1 TR001881 / NCATS NIH HHS U01 AG016976 / NIA NIH HHS 615603 / European Research Council RG/15/12/31616 / British Heart Foundation 647648 / European Research Council MR/J012165/1 / Medical Research Council T32 AG000186 / NIA NIH HHS R01 AG042568 / NIA NIH HHS
Identifiers: 99929056602346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Abstract

Metrics

Details

Usage Policy