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Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.
Journal article   Peer reviewed

Exon-array profiling unlocks clinically and biologically relevant gene signatures from formalin-fixed paraffin-embedded tumour samples.

JS Hall, HS Leong, LS Armenoult, GE Newton, HR Valentine, JJ Irlam, C Möller-Levet, KA Sikand, SD Pepper, CJ Miller, …
Br J Cancer, Vol.104(6), pp.971-981
15/03/2011
DOI: https://doi.org/10.1038/bjc.2011.66

Abstract

Adenocarcinoma Biopsy Carcinoma Non-Small-Cell Lung Carcinoma Squamous Cell Exons Female Fixatives Formaldehyde Gene Expression Profiling Humans Microarray Analysis Neoplasms Paraffin Embedding Time Factors Tissue Fixation Tissue Preservation Uterine Cervical Neoplasms
Degradation and chemical modification of RNA in formalin-fixed paraffin-embedded (FFPE) samples hamper their use in expression profiling studies. This study aimed to show that useful information can be obtained by Exon-array profiling archival FFPE tumour samples.
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http://www.ncbi.nlm.nih.gov/pubmed/21407225View
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