Abstract
<p>Estimating the reproducibility of psychotherapy effects is essential. This is particularly crucial for trials with large effects, as the inclusion of false-positive trials can lead to erroneous conclusions about treatment efficacy in research syntheses.<p> <p>Multicenter studies allow researchers to estimate the reproducibility of effects directly across centers under comparable study conditions (e.g., comparable enrollment procedures, inclusion/exclusion criteria, assessment plans). In an important sense, implementation of trials at various centers is close to a direct replication of findings. Accordingly, recent standards recognize the benefit of describing individual center effects in multicenter studies.</p>