Abstract
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Rotarix® had very good vaccine effectiveness (VE) in UK public health use.
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Two-dose VE against confirmed infection in young children was 77% (95%CI:66–85%)
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The vaccine programme was exceptionally successful (>90% vaccine uptake, high VE)
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Thus, it is highly likely that most acute gastroenteritis (AGE) was no longer due to rotavirus.
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This explains the lack of demonstrable VE against all-cause AGE.