Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

Claudia Filippone; Guillaume Castel; Séverine Murri; Frédérik Beaulieux; Myriam Ermonval; Corinne Jallet; EMMA WISE; RJ Ellis; Denise Marston; Lorraine McElhinney; A. R. Fooks; Amélie Desvars; Lénaı G Halos; Gwenaël Vourc'h; Philippe Marianneau; Noël Tordo

doi:10.1099/jgv.0.000440

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Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

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Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

Claudia Filippone, Guillaume Castel, Séverine Murri, Frédérik Beaulieux, Myriam Ermonval, Corinne Jallet, EMMA WISE, RJ Ellis, Denise Marston, Lorraine McElhinney, …

Journal of General Virology, Vol.97(5), pp.1060-1065

30/04/2016

DOI: https://doi.org/10.1099/jgv.0.000440

PMCID: PMC4851257

PMID: 26932442

Abstract

Microbiology and Parasitology

Life Sciences

Virology

Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.

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Title: Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean
Creators: Claudia Filippone - Stratégies antivirales
Guillaume Castel - Centre de Biologie pour la Gestion des Populations
Séverine Murri - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
Frédérik Beaulieux - Hôpital de la Croix-Rousse [CHU - HCL]
Myriam Ermonval - Stratégies antivirales
Corinne Jallet - Stratégies antivirales
EMMA WISE
RJ Ellis - Wildlife Zoonoses and Vector-borne Diseases Research Group
Denise Marston - Wildlife Zoonoses and Vector-borne Diseases Research Group
Lorraine McElhinney - Wildlife Zoonoses and Vector-borne Diseases Research Group
A. R. Fooks - Wildlife Zoonoses and Vector-borne Diseases Research Group
Amélie Desvars - Animal Epidemiology Research Unit
Lénaı G Halos - Mérial [Lyon]
Gwenaël Vourc'h - Animal Epidemiology Research Unit
Philippe Marianneau - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
Noël Tordo - Stratégies antivirales
Publication Details: Journal of General Virology, Vol.97(5), pp.1060-1065
Publisher: Microbiology Society
Date published: 30/04/2016
Grant note: This study was supported by the EU FP7 programmes: EDENext (no. 261504), EMPERIE (no. 223498), ANTIGONE (no. 278976) and the Research Infrastructure Grant European Virus Archive(no. 19 228292). We thank Sandra Lacote (Virology Unit, Anses-Laboratoire, Lyon, France) for helping during RNA extraction. A. R. F. was supported by the Research and Policy for Infectious Disease Dynamics Program (RAPIDD), Science and Technology Directorate, US Department of Homeland Security and Fogarty International Center, US National Institutes of Health. Sampling was supported by the French Research National Agency ChikAni(ANR no. 06SEST06). We thank all the people who have participated in the collection of data in the field. We thank Dr Alexander Plyusnin for critical reading of the manuscript.
Identifiers: 99553722602346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean

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