Digitalized transcranial electrical stimulation: A consensus statement

Andre R Brunoni; Hamed Ekhtiari; Andrea Antal; Paradee Auvichayapat; Chris Baeken; Isabela M Benseñor; Marom Bikson; Paulo Boggio; Barbara Borroni; Filippo Brighina; Jerome Brunelin; Sandra Carvalho; Wolnei Caumo; Patrick Ciechanski; Leigh Charvet; Vincent P Clark; Roi Cohen Kadosh; Maria Cotelli; Abhishek Datta; Zhi-De Deng; Rudi De Raedt; Dirk De Ridder; Paul B Fitzgerald; Agnes Floel; Flavio Frohlich; Mark S George; Peyman Ghobadi-Azbari; Stephan Goerigk; Roy H Hamilton; Shapour J Jaberzadeh; Kate Hoy; Dawson J Kidgell; Arash Khojasteh Zonoozi; Adam Kirton; Steven Laureys; Michal Lavidor; Kiwon Lee; Jorge Leite; Sarah H Lisanby; Colleen Loo; Donel M Martin; Carlo Miniussi; Marine Mondino; Katia Monte-Silva; Leon Morales-Quezada; Michael A Nitsche; Alexandre H Okano; Claudia S Oliveira; Balder Onarheim; Kevin Pacheco-Barrios; Frank Padberg; Ester M Nakamura-Palacios; Ulrich Palm; Walter Paulus; Christian Plewnia; Alberto Priori; Tarek K Rajji; Lais B Razza; Erik M Rehn; Giulio Ruffini; Klaus Schellhorn; Mehran Zare-Bidoky; Marcel Simis; Pawel Skorupinski; Paulo Suen; Aurore Thibaut; Leandro C L Valiengo; Marie-Anne Vanderhasselt; Sven Vanneste; Ganesan Venkatasubramanian; Ines R Violante; Anna Wexler; Adam J Woods; Felipe Fregni

doi:10.1016/j.clinph.2022.08.018

Back

Digitalized transcranial electrical stimulation: A consensus statement

Journal article

Peer reviewed

Digitalized transcranial electrical stimulation: A consensus statement

Andre R Brunoni, Hamed Ekhtiari, Andrea Antal, Paradee Auvichayapat, Chris Baeken, Isabela M Benseñor, Marom Bikson, Paulo Boggio, Barbara Borroni, Filippo Brighina, …

Clinical neurophysiology, Vol.143, pp.154-165

11/2022

DOI: https://doi.org/10.1016/j.clinph.2022.08.018

PMID: 36115809

Abstract

Consensus

Electric Stimulation

Humans

Transcranial Direct Current Stimulation - methods

Telemedicine

Although relatively costly and non-scalable, non-invasive neuromodulation interventions are treatment alternatives for neuropsychiatric disorders. The recent developments of highly-deployable transcranial electric stimulation (tES) systems, combined with mobile-Health technologies, could be incorporated in digital trials to overcome methodological barriers and increase equity of access. The study aims are to discuss the implementation of tES digital trials by performing a systematic scoping review and strategic process mapping, evaluate methodological aspects of tES digital trial designs, and provide Delphi-based recommendations for implementing digital trials using tES. We convened 61 highly-productive specialists and contacted 8 tES companies to assess 71 issues related to tES digitalization readiness, and processes, barriers, advantages, and opportunities for implementing tES digital trials. Delphi-based recommendations (>60% agreement) were provided. The main strengths/opportunities of tES were: (i) non-pharmacological nature (92% of agreement), safety of these techniques (80%), affordability (88%), and potential scalability (78%). As for weaknesses/threats, we listed insufficient supervision (76%) and unclear regulatory status (69%). Many issues related to methodological biases did not reach consensus. Device appraisal showed moderate digitalization readiness, with high safety and potential for trial implementation, but low connectivity. Panelists recognized the potential of tES for scalability, generalizability, and leverage of digital trials processes; with no consensus about aspects regarding methodological biases. We further propose and discuss a conceptual framework for exploiting shared aspects between mobile-Health tES technologies with digital trials methodology to drive future efforts for digitizing tES trials.

Metrics

4 Record Views

11 Times Cited - Web of Science

See more details

Details

Title: Digitalized transcranial electrical stimulation: A consensus statement
Creators: Andre R Brunoni - Universidade de São Paulo
Hamed Ekhtiari - Laureate Institute for Brain Research
Andrea Antal - Universitätsmedizin Göttingen
Paradee Auvichayapat - Khon Kaen University
Chris Baeken - Vrije Universiteit Brussel
Isabela M Benseñor - Universidade de São Paulo
Marom Bikson - City College of New York
Paulo Boggio - Universidade Presbiteriana Mackenzie
Barbara Borroni - University of Brescia
Filippo Brighina - University of Palermo
Jerome Brunelin - Lyon Neuroscience Research Center
Sandra Carvalho - University of Aveiro
Wolnei Caumo - Universidade Federal do Rio Grande do Sul
Patrick Ciechanski - University of Alberta
Leigh Charvet - New York University
Vincent P Clark - University of New Mexico
Roi Cohen Kadosh - University of Surrey, School of Psychology
Maria Cotelli - Centro San Giovanni di Dio Fatebenefratelli
Abhishek Datta - Soterix Medical
Zhi-De Deng - National Institute of Mental Health
Rudi De Raedt - Ghent University, Belgium
Dirk De Ridder - University of Otago
Paul B Fitzgerald - Monash University
Agnes Floel - German Center for Neurodegenerative Diseases
Flavio Frohlich - University of North Carolina at Chapel Hill
Mark S George - Medical University of South Carolina
Peyman Ghobadi-Azbari - Tehran University of Medical Sciences
Stephan Goerigk - Hochschule Fresenius
Roy H Hamilton - University of Pennsylvania
Shapour J Jaberzadeh - Monash University
Kate Hoy - Monash University
Dawson J Kidgell - Monash University
Arash Khojasteh Zonoozi - Tehran University of Medical Sciences
Adam Kirton - University of Calgary
Steven Laureys - University of Liège
Michal Lavidor - Bar-Ilan University
Kiwon Lee - Ybrain Corporation, Gyeonggi-do, Republic of Korea
Jorge Leite - Universidade do Porto
Sarah H Lisanby - Noninvasive Neuromodulation Unit, Experimental Therapeutics & Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, USA
Colleen Loo - University of New South Wales
Donel M Martin - University of New South Wales
Carlo Miniussi - University of Trento
Marine Mondino - University of Palermo
Katia Monte-Silva - Universidade Federal de Pernambuco
Leon Morales-Quezada - Spaulding Rehabilitation Hospital
Michael A Nitsche - Leibniz Research Centre for Working Environment and Human Factors
Alexandre H Okano - University of Campinas, Campinas, São Paulo, Brazil
Claudia S Oliveira - Faculdade de Ciências Médicas da Santa Casa de São Paulo
Balder Onarheim - APS
Kevin Pacheco-Barrios - Harvard Medical School
Frank Padberg - Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany
Ester M Nakamura-Palacios - Laboratory of Cognitive Sciences and Neuropsychopharmacology, Program of Post-Graduation in Physiological Sciences, Health Sciences Center, Federal University of Espirito Santo, Vitória, ES, Brazil
Ulrich Palm - Klinikum der Universität München, Munich, Germany
Walter Paulus - Ludwig Maximilian University of Munich
Christian Plewnia - University of Tübingen
Alberto Priori - University of Milan
Tarek K Rajji - University of Toronto
Lais B Razza - Universidade de São Paulo
Erik M Rehn - Flow Neuroscience
Giulio Ruffini - Neuroelectrics Corporation, Cambridge, MA, USA
Klaus Schellhorn - neuroConn GmbH, Ilmenau, Germany
Mehran Zare-Bidoky - Tehran University of Medical Sciences
Marcel Simis - University of Sao Paulo
Pawel Skorupinski - Neuroelectrics Corporation, Cambridge, MA, USA
Paulo Suen - Universidade Presbiteriana Mackenzie
Aurore Thibaut - Coma Science Group, GIGA-Consciousness & Centre du Cerveau, University and University Hospital of Liège, Liège, Belgium
Leandro C L Valiengo - Universidade de São Paulo
Marie-Anne Vanderhasselt - Ghent University
Sven Vanneste - Trinity College Dublin
Ganesan Venkatasubramanian - Montreal Neurological Institute and Hospital
Ines R Violante - University of Surrey, School of Psychology
Anna Wexler - University of Pennsylvania
Adam J Woods - University of Florida
Felipe Fregni - Spaulding Rehabilitation Hospital
Publication Details: Clinical neurophysiology, Vol.143, pp.154-165
Date published: 11/2022
Grant note: R01 HD082302 / NICHD NIH HHS
Identifiers: 99783699302346
Academic Unit: School of Psychology
Language: English
Resource Type: Journal article

Digitalized transcranial electrical stimulation: A consensus statement

Abstract

Metrics

Details

Usage Policy