DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

JR Mercer; KK Cheng; N Figg; I Gorenne; M Mahmoudi; J Griffin; A Vidal-Puig; A Logan; MP Murphy; M Bennett

doi:10.1161/CIRCRESAHA.110.218966

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DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

Journal article

Peer reviewed

DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

JR Mercer, KK Cheng, N Figg, I Gorenne, M Mahmoudi, J Griffin, A Vidal-Puig, A Logan, MP Murphy and M Bennett

Circ Res, Vol.107(8), pp.1021-1031

15/10/2010

DOI: https://doi.org/10.1161/CIRCRESAHA.110.218966

Abstract

Animals

Apolipoproteins E

Atherosclerosis

Cell Cycle Proteins

DNA Damage

DNA

Mitochondrial

DNA-Binding Proteins

Dietary Fats

Haplotypes

Hyperlipidemias

Metabolic Syndrome X

Metabolomics

Mice

Mutant Strains

Mitochondria

Muscle

Smooth

Vascular

Oxidative Phosphorylation

Protein-Serine-Threonine Kinases

Tumor Suppressor Proteins

DNA damage is present in both genomic and mitochondrial DNA in atherosclerosis. However, whether DNA damage itself promotes atherosclerosis, or is simply a byproduct of the risk factors that promote atherosclerosis, is unknown.

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Title: DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.
Creators: JR Mercer
KK Cheng
N Figg
I Gorenne
M Mahmoudi
J Griffin
A Vidal-Puig
A Logan
MP Murphy
M Bennett
Publication Details: Circ Res, Vol.107(8), pp.1021-1031
Date published: 15/10/2010
Date submitted: 17/05/2017
Identifiers: 99513717102346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

Abstract

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