Abstract
In this work, we
report the new protocols that are developed to
determine the shape factors of Form I paracetamol crystals using a
combination of techniques that rely on the state-of-the-art X-ray
computed tomography and Morphologi G3. The determined shape factors
successfully predicted the crystal growth rate of paracetamol in 2-propanol
and the length of the crystals growing in the supersaturated solution. X-ray computed tomography and optical
microscopy can be
effectively combined to predict crystal shape factors with reasonable
accuracy.