Convenient synthesis of protected primary amines from nitriles

Stephen Caddick; Alexandra K de K. Haynes; Duncan B Judd; Meredith R.V Williams; ALEXANDRA KATHERINE DE KIRIAN LEWIS

doi:10.1016/S0040-4039(00)00410-X

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Convenient synthesis of protected primary amines from nitriles

Journal article

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Convenient synthesis of protected primary amines from nitriles

Stephen Caddick, Alexandra K de K. Haynes, Duncan B Judd, Meredith R.V Williams and ALEXANDRA KATHERINE DE KIRIAN LEWIS

Tetrahedron letters, Vol.41(18), pp.3513-3516

29/04/2000

DOI: https://doi.org/10.1016/S0040-4039(00)00410-X

Abstract

dimerisation

nickel boride

nitriles

reduction

Investigations into the use of nickel chloride and sodium borohydride for the reduction of nitriles showed the secondary amine dimers to be the major products under normal conditions. The addition of a suitable trapping agent, such as di- tert-butyl dicarbonate, allowed the isolation of the protected primary amines.

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Title: Convenient synthesis of protected primary amines from nitriles
Creators: Stephen Caddick - University of Sussex
Alexandra K de K. Haynes - University of Sussex
Duncan B Judd - Lead Design, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Meredith R.V Williams - University of Sussex
ALEXANDRA KATHERINE DE KIRIAN LEWIS - Research Strategy
Publication Details: Tetrahedron letters, Vol.41(18), pp.3513-3516
Publisher: Elsevier Ltd
Date published: 29/04/2000
Identifiers: 99783056402346
Academic Unit: Research Strategy
Language: English
Resource Type: Journal article

Convenient synthesis of protected primary amines from nitriles

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