Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Fergus J. Couch; Chris Jacobs; Mia M. Gaudet; Antonis C. Antoniou; Susan J. Ramus; Karoline B. Kuchenbaecker; Penny Soucy; Jonathan Beesley; Xiaoqing Chen; Xianshu Wang; Tomas Kirchhoff; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Sue Healey; Olga M. Sinilnikova; Irene L. Andrulis; Hilmi Ozcelik; Anna Marie Mulligan; Mads Thomassen; Anne-Marie Gerdes; Uffe Birk Jensen; Anne-Bine Skytte; Torben A. Kruse; Maria A. Caligo; Anna von Wachenfeldt; Gisela Barbany-Bustinza; Niklas Loman; Maria Soller; Hans Ehrencrona; Per Karlsson; Katherine L. Nathanson; Timothy R. Rebbeck; Susan M. Domchek; Ania Jakubowska; Jan Lubinski; Katarzyna Jaworska; Katarzyna Durda; Elzbieta Zlowocka; Tomasz Huzarski; Tomasz Byrski; Jacek Gronwald; Cezary Cybulski; Bohdan Gorski; Ana Osorio; Mercedes Duran; Maria Isabel Tejada; Javier Benitez; Ute Hamann; Frans B. L. Hogervorst; Theo A. van Os; Flora E. van Leeuwen; Hanne E. J. Meijers-Heijboer; Juul Wijnen; Marinus J. Blok; Marleen Kets; Maartje J. Hooning; Rogier A. Oldenburg; Margreet G. E. M. Ausems; Susan Peock; Debra Frost; Steve D. Ellis; Radka Platte; Elena Fineberg; D. Gareth Evans; Rosalind A. Eeles; Julian Adlard; Rosemarie Davidson; Diana M. Eccles; Trevor Cole; Jackie Cook; Joan Paterson; Carole Brewer; Fiona Douglas; Shirley V. Hodgson; Patrick J. Morrison; Lisa Walker; Mary E. Porteous; M. John Kennedy; Lucy E. Side; Betsy Bove; Andrew K. Godwin; Dominique Stoppa-Lyonnet; Marion Fassy-Colcombet; Laurent Castera; Francois Cornelis; Sylvie Mazoyer; Melanie Leone; Nadia Boutry-Kryza; Brigitte Bressac-de Paillerets; Olivier Caron; Pascal Pujol; Isabelle Coupier; Capucine Delnatte; Linda Akloul; Henry T. Lynch; Carrie L. Snyder; Saundra S. Buys; Mary B. Daly; MaryBeth Terry; Wendy K. Chung; Esther M. John; Alexander Miron; Melissa C. Southey; John L. Hopper; David E. Goldgar; Christian F. Singer; Christine Rappaport; Muy-Kheng M. Tea; Anneliese Fink-Retter; Thomas V. O. Hansen; Finn C. Nielsen; Adalgeir Arason; Joseph Vijai; Sohela Shah; Kara Sarrel; Mark E. Robson; Marion Piedmonte; Kelly Phillips; Jack Basil; Wendy S. Rubinstein; John Boggess; Katie Wakeley; Amanda Ewart-Toland; Marco Montagna; Simona Agata; Evgeny N. Imyanitov; Claudine Isaacs; Ramunas Janavicius; Conxi Lazaro; Ignacio Blanco; Lidia Feliubadalo; Joan Brunet; Simon A. Gayther; Paul P. D. Pharoah; Kunle O. Odunsi; Beth Y. Karlan; Christine S. Walsh; Edith Olah; Soo Hwang Teo; Patricia A. Ganz; Mary S. Beattie; Elizabeth J. van Rensburg; Cecelia M. Dorfling; Orland Diez; Ava Kwong; Rita K. Schmutzler; Barbara Wappenschmidt; Christoph Engel; Alfons Meindl; Nina Ditsch; Norbert Arnold; Simone Heidemann; Dieter Niederacher; Sabine Preisler-Adams; Dorothea Gadzicki; Raymonda Varon-Mateeva; Helmut Deissler; Andrea Gehrig; Christian Sutter; Karin Kast; Britta Fiebig; Wolfram Heinritz; Trinidad Caldes; Miguel de la Hoya; Taru A. Muranen; Heli Nevanlinna; Marcd Tischkowitz; Amanda B. Spurdle; Susan L. Neuhausen; Yuan Chun Ding; Noralane M. Lindor; Zachary Fredericksen; V. Shane Pankratz; Paolo Peterlongo; Siranoush Manoukian; Bernard Peissel; Daniela Zaffaroni; Monica Barile; Loris Bernard; Alessandra Viel; Giuseppe Giannini; Liliana Varesco; Paolo Radice; Mark H. Greene; Phuong L. Mai; Douglas F. Easton; Georgia Chenevix-Trench; Kenneth Offit; Jacques Simard; kConFab Investigators

doi:10.1158/1055-9965.EPI-11-0888

Back

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Journal article

Open access

Peer reviewed

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Fergus J. Couch, Chris Jacobs, Mia M. Gaudet, Antonis C. Antoniou, Susan J. Ramus, Karoline B. Kuchenbaecker, Penny Soucy, Jonathan Beesley, Xiaoqing Chen, Xianshu Wang, …

Cancer epidemiology, biomarkers & prevention, Vol.21(4), pp.645-657

2012

DOI: https://doi.org/10.1158/1055-9965.EPI-11-0888

PMCID: PMC3319317

PMID: 22351618

Abstract

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

Oncology

Background: Genome-wide association studies (GWAS) identified variants at 19p13.1 and ZNF365 (10q21.2) as risk factors for breast cancer among BRCA1 and BRCA2 mutation carriers, respectively. We explored associations with ovarian cancer and with breast cancer by tumor histopathology for these variants in mutation carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Methods: Genotyping data for 12,599 BRCA1 and 7,132 BRCA2 mutation carriers from 40 studies were combined. Results: We confirmed associations between rs8170 at 19p13.1 and breast cancer risk for BRCA1 mutation carriers [HR, 1.17; 95% confidence interval (CI), 1.07-1.27; P = 7.42 x 10(-4)] and between rs16917302 at ZNF365 (HR, 0.84; 95% CI, 0.73-0.97; P = 0.017) but not rs311499 at 20q13.3 (HR, 1.11; 95% CI, 0.94-1.31; P = 0.22) and breast cancer risk for BRCA2 mutation carriers. Analyses based on tumor histopathology showed that 19p13 variants were predominantly associated with estrogen receptor (ER)-negative breast cancer for both BRCA1 and BRCA2 mutation carriers, whereas rs16917302 at ZNF365 was mainly associated with ER-positive breast cancer for both BRCA1 and BRCA2 mutation carriers. We also found for the first time that rs67397200 at 19p13.1 was associated with an increased risk of ovarian cancer for BRCA1 (HR, 1.16; 95% CI, 1.05-1.29; P = 3.8 x 10(-4)) and BRCA2 mutation carriers (HR, 1.30; 95% CI, 1.10-1.52; P = 1.8 x 10(-3)). Conclusions: 19p13.1 and ZNF365 are susceptibility loci for ovarian cancer and ER subtypes of breast cancer among BRCA1 and BRCA2 mutation carriers. Impact: These findings can lead to an improved understanding of tumor development and may prove useful for breast and ovarian cancer risk prediction for BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev; 21(4); 645-57. (C) 2012 AACR.

Files and links (1)

url

https://doi.org/10.1158/1055-9965.EPI-11-0888View

Published (Version of record) Open

Metrics

3 Record Views

40 Times Cited - Web of Science

See more details

Details

Title: Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Creators: Fergus J. Couch - Lund University
Chris Jacobs - Centre for Life
Mia M. Gaudet - Birmingham Women's Hospital
Antonis C. Antoniou - Centre for Life
Susan J. Ramus - Royal Devon and Exeter Hospital
Karoline B. Kuchenbaecker - Postgraduate School of Molecular Medicine
Penny Soucy - Pomeranian Medical University
Jonathan Beesley - Birmingham Women's Hospital
Xiaoqing Chen - Birmingham Women's Hospital
Xianshu Wang - Centre for Life
Tomas Kirchhoff - Centre for Life
Lesley McGuffog - Birmingham Women's Hospital
Daniel Barrowdale - Birmingham Women's Hospital
Andrew Lee - Sheffield Children's Hospital
Sue Healey - Centre for Life
Olga M. Sinilnikova - Royal Devon and Exeter Hospital
Irene L. Andrulis - Subang Jaya Medical Centre
Hilmi Ozcelik - Comprehensive Cancer Center Vienna
Anna Marie Mulligan - QIMR Berghofer Medical Research Institute
Mads Thomassen - Erasmus MC
Anne-Marie Gerdes - Rigshosp, Dept Clin Genet, Copenhagen, Denmark
Uffe Birk Jensen - Centre for Life
Anne-Bine Skytte - Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Torben A. Kruse - Churchill Hospital
Maria A. Caligo - Sheffield Children's Hospital
Anna von Wachenfeldt - Postgraduate School of Molecular Medicine
Gisela Barbany-Bustinza - Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden
Niklas Loman - Pomeranian Medical University
Maria Soller - Centre for Life
Hans Ehrencrona - Cancer Research Malaysia
Per Karlsson - University Medical Center Utrecht
Katherine L. Nathanson - Hampton University
Timothy R. Rebbeck - Fox Chase Cancer Center
Susan M. Domchek - Sheffield Children's Hospital
Ania Jakubowska - College Station Medical Center
Jan Lubinski - Birmingham Women's Hospital
Katarzyna Jaworska - Royal Devon and Exeter Hospital
Katarzyna Durda - Sheffield Children's Hospital
Elzbieta Zlowocka - College Station Medical Center
Tomasz Huzarski - Sheffield Children's Hospital
Tomasz Byrski - Birmingham Women's Hospital
Jacek Gronwald - Centre for Life
Cezary Cybulski - Pomeranian Medical University
Bohdan Gorski - Centre for Life
Ana Osorio - Centre for Life
Mercedes Duran - Centre for Life
Maria Isabel Tejada - Cruces Hosp Barakaldo, Dept Biochem, Mol Genet Lab, Bizkaia, Spain
Javier Benitez - Spanish Natl Canc Res Ctr, Human Canc Genet Programme, Human Genet Grp, Madrid, Spain
Ute Hamann - Sheffield Children's Hospital
Frans B. L. Hogervorst - Birmingham Women's Hospital
Theo A. van Os - Centre for Life
Flora E. van Leeuwen - Postgraduate School of Molecular Medicine
Hanne E. J. Meijers-Heijboer - University of Amsterdam
Juul Wijnen - Erasmus MC
Marinus J. Blok - Centre for Life
Marleen Kets - Birmingham Women's Hospital
Maartje J. Hooning - Sheffield Children's Hospital
Rogier A. Oldenburg - University Hospital Carl Gustav Carus
Margreet G. E. M. Ausems - Birmingham Women's Hospital
Susan Peock - Pomeranian Medical University
Debra Frost - Sheffield Children's Hospital
Steve D. Ellis - Erasmus MC
Radka Platte - Centre Hospitalier Sud Francilien
Elena Fineberg - Birmingham Women's Hospital
D. Gareth Evans - Columbia University
Rosalind A. Eeles - Centre for Life
Julian Adlard - Birmingham Women's Hospital
Rosemarie Davidson - Sheffield Children's Hospital
Diana M. Eccles - Sheffield Children's Hospital
Trevor Cole - Sheffield Children's Hospital
Jackie Cook - Sheffield Children's Hospital
Joan Paterson - Centre for Life
Carole Brewer - Centre for Life
Fiona Douglas - Uppsala University
Shirley V. Hodgson - Birmingham Women's Hospital
Patrick J. Morrison - Royal Devon and Exeter Hospital
Lisa Walker - Royal Devon and Exeter Hospital
Mary E. Porteous - Birmingham Women's Hospital
M. John Kennedy - Peter MacCallum Cancer Centre
Lucy E. Side - Woolmanhill Hospital
Betsy Bove - Centre for Life
Andrew K. Godwin - Centre for Life
Dominique Stoppa-Lyonnet - Federat Natl Ctr Lutte Canc, GEMO Study Collaborators Canc Genet Network, Grp Genet & Canc, Lyon, France
Marion Fassy-Colcombet - University of Melbourne
Laurent Castera - Erasmus MC
Francois Cornelis - Royal Marsden NHS Foundation Trust
Sylvie Mazoyer - Centre for Life
Melanie Leone - Columbia University
Nadia Boutry-Kryza - Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France
Brigitte Bressac-de Paillerets - Inst Cancerol Gustave Roussy, Dept Genet, Villejuif, France
Olivier Caron - Fox Chase Cancer Center
Pascal Pujol - Centre for Life
Isabelle Coupier - Centre for Life
Capucine Delnatte - College Station Medical Center
Linda Akloul - Centre for Life
Henry T. Lynch - Centre for Life
Carrie L. Snyder - Birmingham Women's Hospital
Saundra S. Buys - Birmingham Women's Hospital
Mary B. Daly - Birmingham Women's Hospital
MaryBeth Terry - Columbia University
Wendy K. Chung - Birmingham Women's Hospital
Esther M. John - American Cancer Society
Alexander Miron - Birmingham Women's Hospital
Melissa C. Southey - Radboud University Nijmegen
John L. Hopper - Erasmus MC
David E. Goldgar - Karolinska University Hospital
Christian F. Singer - Birmingham Women's Hospital
Christine Rappaport - University Hospital Carl Gustav Carus
Muy-Kheng M. Tea - University of Vienna
Anneliese Fink-Retter - Postgraduate School of Molecular Medicine
Thomas V. O. Hansen - Instituto de Biología y Genética Molecular
Finn C. Nielsen - Hampton University
Adalgeir Arason - National University Hospital of Iceland
Joseph Vijai - Birmingham Women's Hospital
Sohela Shah - Centre for Life
Kara Sarrel - Sheffield Children's Hospital
Mark E. Robson - Birmingham Women's Hospital
Marion Piedmonte - Centre for Life
Kelly Phillips - University of Melbourne
Jack Basil - Centre for Life
Wendy S. Rubinstein - Royal Devon and Exeter Hospital
John Boggess - Centre for Life
Katie Wakeley - Centre for Life
Amanda Ewart-Toland - The Ohio State University
Marco Montagna - Centre for Life
Simona Agata - Birmingham Women's Hospital
Evgeny N. Imyanitov - Centre for Life
Claudine Isaacs - Sheffield Children's Hospital
Ramunas Janavicius - Centre for Life
Conxi Lazaro - Centre for Life
Ignacio Blanco - Centre for Life
Lidia Feliubadalo - Birmingham Women's Hospital
Joan Brunet - Sheffield Children's Hospital
Simon A. Gayther - Birmingham Women's Hospital
Paul P. D. Pharoah - University of Cambridge
Kunle O. Odunsi - Birmingham Women's Hospital
Beth Y. Karlan - Birmingham Women's Hospital
Christine S. Walsh - Sheffield Children's Hospital
Edith Olah - Centre for Life
Soo Hwang Teo - Centre for Life
Patricia A. Ganz - Centre for Life
Mary S. Beattie - Centre Hospitalier Sud Francilien
Elizabeth J. van Rensburg - Centre for Life
Cecelia M. Dorfling - Fox Chase Cancer Center
Orland Diez - Centre for Life
Ava Kwong - Sheffield Children's Hospital
Rita K. Schmutzler - Sheffield Children's Hospital
Barbara Wappenschmidt - Birmingham Women's Hospital
Christoph Engel - Birmingham Women's Hospital
Alfons Meindl - Birmingham Women's Hospital
Nina Ditsch - Centre for Life
Norbert Arnold - Birmingham Women's Hospital
Simone Heidemann - Centre for Life
Dieter Niederacher - Centre for Life
Sabine Preisler-Adams - Birmingham Women's Hospital
Dorothea Gadzicki - Centre for Life
Raymonda Varon-Mateeva - Postgraduate School of Molecular Medicine
Helmut Deissler - Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Andrea Gehrig - Birmingham Women's Hospital
Christian Sutter - Copenhagen University Hospital
Karin Kast - Trinity College Dublin
Britta Fiebig - University Medical Center Utrecht
Wolfram Heinritz - Uppsala University
Trinidad Caldes - Birmingham Women's Hospital
Miguel de la Hoya - Birmingham Women's Hospital
Taru A. Muranen - Birmingham Women's Hospital
Heli Nevanlinna - Birmingham Women's Hospital
Marcd Tischkowitz - McGill University
Amanda B. Spurdle - Sheffield Children's Hospital
Susan L. Neuhausen - City of Hope
Yuan Chun Ding - Centre for Life
Noralane M. Lindor - Birmingham Women's Hospital
Zachary Fredericksen - Birmingham Women's Hospital
V. Shane Pankratz - Birmingham Women's Hospital
Paolo Peterlongo - Birmingham Women's Hospital
Siranoush Manoukian - University Hospital Carl Gustav Carus
Bernard Peissel - Sheffield Children's Hospital
Daniela Zaffaroni - Birmingham Women's Hospital
Monica Barile - Birmingham Women's Hospital
Loris Bernard - Centre for Life
Alessandra Viel - Centre for Life
Giuseppe Giannini - Birmingham Women's Hospital
Liliana Varesco - Birmingham Women's Hospital
Paolo Radice - Birmingham Women's Hospital
Mark H. Greene - National Cancer Institute
Phuong L. Mai - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, Rockville, MD USA
Douglas F. Easton - University of Cambridge
Georgia Chenevix-Trench - Institute of Human Genetics
Kenneth Offit - Birmingham Women's Hospital
Jacques Simard - Centre for Life
kConFab Investigators
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.21(4), pp.645-657
Publisher: Amer Assoc Cancer Research
Number of pages: 13
Date published: 2012
Grant note: BIO07/CA/006 / Basque Foundation for Health Innovation and Research (BIOEF) Fundacion Mutua Madrilena; Instituto de Salud Carlos III Fondazione Italiana per la Ricerca sul Cancro; Fondazione AIRC per la ricerca sul cancro Neye Foundation 132473 / Academy of Finland; Research Council of Finland Autonomous Government of Catalonia; Generalitat de Catalunya AICR-07-0454 / Association for International Cancer Research Grant Komen Foundation for the Cure; Susan G. Komen Breast Cancer Foundation 223175 (HEALTH-F2-2009-223175) / European Community C1287/A10118; C1287/A11990 / CR-UK; Cancer Research UK Kate and Robert Niehaus Clinical Cancer Research Initiative CARIF LIG-19/2010 / Research Council of Lithuania; Research Council of Lithuania (LMTLT) P30-CA051008 / Familial Cancer Registry at Georgetown University (NIH/NCI) W81XWH-10-1-0341 / U.S. Department of Defence; United States Department of Defense Association "Le cancer du sein, parlons-en!" Catalan Health Institute University of Kansas Cancer Center CRUK; Cancer Research UK CA-06-503 / U.S. National Cancer Institute, NIH under RFA 91109024 / ZonMW; Netherlands Organization for Health Research and Development National Breast Cancer Foundation 109076 / German Cancer Aid; Deutsche Krebshilfe Sigrid Juselius Foundation RFPS 2006-5-341353; ACC2/R6.9 / "Ministero della Salute"; Ministry of Health, Italy Landspitali University Hospital FIS PI08 1120 / Spanish Ministry of Science and Innovation; Spanish Government Royal Marsden NHS Foundation Trust; Royal Society of New Zealand; Marsden Fund (NZ) 10124 / Cancer Research UK; The Francis Crick Institute; Cancer Research UK SIOP-06-258-06-COUN / American Cancer Society 145684; 288704; 454508 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia Sabin Family Research Initiative C12292/A11174; C1287/A10118 / Cancer Research UK (CR-UK); Cancer Research UK 16.512.11.2237 / Federal Agency for Science and Innovations; Federal Agency for Science & Innovations (FASI) Cancer Foundation of Western Australia; Cancer Council Western Australia Jewish General Hospital Starr Cancer Consortium Breast Cancer Family Registry (BCFR) DKFZ; Helmholtz Association 10-04-92601; 10-04-92110; 11-04-00227 / Russian Federation for Basic Research; Russian Foundation for Basic Research (RFBR) Ohio State University Comprehensive Cancer Center 019511 / Canadian Breast Cancer Research Alliance Cancer Care Ontario HHSN261200744000C / Cancer Genetics Network CA116201 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Breast Cancer Research Foundation 4017 / Associazione Italiana per la Ricerca sulCancro; Fondazione AIRC per la ricerca sul cancro Centre of Molecular Medicine Cologne (CMMC) 15007; 11174; 11022; 10118 / Cancer Research UK Helsinki University Central Hospital KTIA-OTKACK-80745 / Hungarian Research Grant CA128978 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RBLAO3-BETH / Ministero dell'Universita' e Ricerca; Ministry of Education, Universities and Research (MIUR) Cancer Councils of New South Wales, Victoria, Tasmania; Cancer Council New South Wales Ministero della Salute; Ministry of Health, Italy Clinical Genetics Branch, DCEG FCCC Lymphoma Foundation Spanish Health Research Fund; Instituto de Salud Carlos III Postgraduate School of Molecular Medicine, Warsaw Medical University Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR); Ministry of Education, Universities and Research (MIUR) U.S. National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Cancer Association of South Africa (CANSA) Center for Translational and Policy Research in Personalized Medicine (TRANSPERS) Community Oncology and Prevention Trials Program-COPTRG Kansas Bioscience Authority Eminent Scholar Program Avon Foundation Finnish Cancer Society Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) Westat, Inc. Queensland Cancer Fund NKI1998-1854; NKI2004-3088; NKI2007-3756 / Dutch Cancer Society; KWF Kankerbestrijding Carlos III Health Institute; Instituto de Salud Carlos III Norman and Carol Stone Cancer Research Initiative RFA-CA-06-503 / National Cancer Institute, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Helen Diller Family Comprehensive Cancer Center at UCSF Ligue National Contre le Cancer; Ligue nationale contre le cancer Polish Foundation of Science University Malaya; Universiti Malaya NF-SI-0510-10096 / National Institute for Health Research; National Institutes of Health Research (NIHR) Instituto Toscano Tumori grant Icelandic Association "Walking for Breast Cancer Research" NIHR; National Institutes of Health Research (NIHR) Fondazione IRCCS Istituto Nazionale Tumori Asociacion Espanola Contra el Cancer Swing Fore the Cure National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia P01 CA130818-02A1 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
Identifiers: 99822359702346
Academic Unit: School of Health Sciences
Language: English
Resource Type: Journal article

Common Variants at the 19p13.1 and ZNF365 Loci Are Associated with ER Subtypes of Breast Cancer and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Abstract

Files and links (1)

Metrics

Details

Usage Policy