Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Brigitta Matta-Domjan; Alice King; Stella Totti; Csaba Matta; George Dover; Patricia Martinez; Anvar Zakhidov; Roberto La Ragione; Hugo Macedo; Izabela Jurewicz; Alan Dalton; Eirini Velliou

doi:10.1002/jbm.b.34012

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Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Journal article

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Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

Brigitta Matta-Domjan, Alice King, Stella Totti, Csaba Matta, George Dover, Patricia Martinez, Anvar Zakhidov, Roberto La Ragione, Hugo Macedo, Izabela Jurewicz, …

Journal of Biomedical Materials Research Part B-Applied Biomaterials, Vol.106(5), pp.1637-1644

04/10/2017

DOI: https://doi.org/10.1002/jbm.b.34012

Abstract

biocompatible pristine carbon nanotube substrate; pancreatic adenocarcinoma; pancreatic cancer tissue engineering; extracellular matrix

Novel synthetic biomaterials able to support, direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds -which are easily tuneable to form sheets/fibres- support growth, proliferation and spatial organisation of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.

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Title: Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering
Creators: Brigitta Matta-Domjan
Alice King
Stella Totti
Csaba Matta
George Dover
Patricia Martinez
Anvar Zakhidov
Roberto La Ragione
Hugo Macedo
Izabela Jurewicz
Alan Dalton
Eirini Velliou
Publication Details: Journal of Biomedical Materials Research Part B-Applied Biomaterials, Vol.106(5), pp.1637-1644
Publisher: Wiley
Date published: 04/10/2017
Date submitted: 19/09/2017
Grant note: Funder: EPSRC -IAA | Funder: EPSRC | Grant ID: 2016/ RN0281J, EP/K031562
Identifiers: 99515247002346
Copyright: This is the peer reviewed version of the following article: Matta-Domjan, B, King, A, Totti, S, Matta, C, Dover, G, Martinez, P, Zakhidov, A, La Ragione, R, Macedo, H, Jurewicz, I, Dalton, A, Velliou, EG 2017. Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering. J Biomed Mater Res Part B 2017:00B:000–000, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.34012/full. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Academic Unit: School of Chemistry and Chemical Engineering
Resource Type: Journal article

Biophysical interactions between pancreatic adenocarcinoma cell lines and pristine carbon nanotube substrates: Potential application for pancreatic cancer tissue engineering

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