Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema; Daan van Rooij; Evdokia Anagnostou; Celso Arango; Guillaume Auzias; Marlene Behrmann; Geraldo Busatto Filho; Sara Calderoni; Rosa Calvo; Eileen Daly; Christine Deruelle; Adriana Di Martino; Ilan Dinstein; Fabio Luis S. Duran; Sarah Durston; Christine Ecker; Stefan Ehrlich; Damien Fair; Jennifer Fedor; Xin Feng; Jackie Fitzgerald; Dorothea L. Floris; Christine M. Freitag; Louise Gallagher; David C. Glahn; Ilaria Gori; Shlomi Haar; Liesbeth Hoekstra; Neda Jahanshad; Maria Jalbrzikowski; Joost Janssen; Joseph A. King; Xiang Zhen Kong; Luisa Lazaro; Jason P. Lerch; Beatriz Luna; Mauricio M. Martinho; Jane McGrath; Sarah E. Medland; Filippo Muratori; Clodagh M. Murphy; Declan G. M. Murphy; Kirsten O'Hearn; Bob Oranje; Mara Parellada; Olga Puig; Alessandra Retico; Pedro Rosa; Katya Rubia; Devon Shook; Margot J. Taylor; Michela Tosetti; Gregory L. Wallace; Fengfeng Zhou; Paul M. Thompson; Simon E. Fisher; Jan K. Buitelaar; Clyde Francks

doi:10.1038/s41467-019-13005-8

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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

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Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema, Daan van Rooij, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Marlene Behrmann, Geraldo Busatto Filho, Sara Calderoni, Rosa Calvo, Eileen Daly, …

Nature communications, Vol.10(1), pp.4958-12

31/10/2019

DOI: https://doi.org/10.1038/s41467-019-13005-8

PMID: 31673008

Abstract

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Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD.

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Title: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets
Creators: Merel C. Postema - Max Planck Institute for Psycholinguistics
Daan van Rooij - Radboud University Nijmegen
Evdokia Anagnostou - University of Toronto
Celso Arango - Hospital General Universitario Gregorio Marañón
Guillaume Auzias - Centre National de la Recherche Scientifique
Marlene Behrmann - Carnegie Mellon University
Geraldo Busatto Filho - Universidade de São Paulo
Sara Calderoni - Fondazione Stella Maris
Rosa Calvo - Universitat de Barcelona
Eileen Daly - King's College London
Christine Deruelle - Aix-Marseille Université
Adriana Di Martino - NYU Child Study Ctr, Inst Pediat Neurosci, New York, NY USA
Ilan Dinstein - Ben-Gurion University of the Negev
Fabio Luis S. Duran - Universidade de São Paulo
Sarah Durston - University Medical Center Utrecht
Christine Ecker - Goethe University Frankfurt
Stefan Ehrlich - TU Dresden
Damien Fair - Oregon Health & Science University
Jennifer Fedor - University of Pittsburgh
Xin Feng - Jilin University
Jackie Fitzgerald - Trinity College Dublin
Dorothea L. Floris - Radboud University Nijmegen
Christine M. Freitag - Goethe University Frankfurt
Louise Gallagher - Trinity College Dublin
David C. Glahn - Boston Children's Hospital
Ilaria Gori - Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
Shlomi Haar - Imperial College London
Liesbeth Hoekstra - Radboud University Nijmegen
Neda Jahanshad - University of Southern California
Maria Jalbrzikowski - Trinity College Dublin
Joost Janssen - Hospital General Universitario Gregorio Marañón
Joseph A. King - TU Dresden
Xiang Zhen Kong - Max Planck Institute for Psycholinguistics
Luisa Lazaro - Universitat de Barcelona
Jason P. Lerch - Hospital for Sick Children
Beatriz Luna - University of Pittsburgh
Mauricio M. Martinho - Universidade Federal de Santa Maria
Jane McGrath - Trinity College Dublin
Sarah E. Medland - QIMR Berghofer Medical Research Institute
Filippo Muratori - University of Pisa
Clodagh M. Murphy - King's College London
Declan G. M. Murphy - South London & Maudsley Fdn NHS Trust, Behav & Dev Psychiat Clin Acad Grp, Behav Genet Clin, Adult Autism Serv, London, England
Kirsten O'Hearn - University of Pittsburgh
Bob Oranje - University Medical Center Utrecht
Mara Parellada - Hospital General Universitario Gregorio Marañón
Olga Puig - Universitat de Barcelona
Alessandra Retico - Istituto Nazionale di Fisica Nucleare
Pedro Rosa - Universidade de São Paulo
Katya Rubia - King's College London
Devon Shook - University Medical Center Utrecht
Margot J. Taylor - University of Toronto
Michela Tosetti - Fondazione Stella Maris
Gregory L. Wallace - George Washington University
Fengfeng Zhou - Jilin University
Paul M. Thompson - University of Southern California
Simon E. Fisher - Radboud University Nijmegen
Jan K. Buitelaar - Radboud University Nijmegen
Clyde Francks - Radboud University Nijmegen
Publication Details: Nature communications, Vol.10(1), pp.4958-12
Publisher: NATURE PORTFOLIO
Number of pages: 12
Publication Date: 31/10/2019
Grant note: European Union; European Union (EU) Max Planck Society (Germany); Max Planck Society European Federation of Pharmaceutical Industries and Associations (EFPIA) 115300; 777394 / Innovative Medicines Initiative Joint Undertaking NIH U54 EB020403 / ENIGMA Center for Worldwide Medicine, Imaging Genomics; European Union (EU) IDSI l-02 / Ontario Brain Institute MR/N026063/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiers: 991006098102346; WOS:000493438700006
Academic Unit: School of Psychology
Language: English
Resource Type: Journal article

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

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