Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

C Ludwig; D S Williams; DAVID  BARTLETT; S Essex; G McNee; J Allwood; E Jewell; A Barkhuisen; H Parry; S Anandram; P Nicolson; C Gardener; F Seymour; S Basu; Warwick B. Dunn; P A H Moss; G Pratt; D A Tennant

doi:10.1038/bcj.2015.85

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Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

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Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

C Ludwig, D S Williams, DAVID BARTLETT, S Essex, G McNee, J Allwood, E Jewell, A Barkhuisen, H Parry, S Anandram, …

Blood cancer journal (New York), Vol.5(10), e359

16/10/2015

DOI: https://doi.org/10.1038/bcj.2015.85

PMCID: PMC4635194

PMID: 26473531

Abstract

Biomarkers, Tumor - analysis

Bone Marrow - metabolism

Bone Marrow - pathology

Humans

Magnetic Resonance Spectroscopy

Metabolome

Monoclonal Gammopathy of Undetermined Significance - metabolism

Monoclonal Gammopathy of Undetermined Significance - pathology

Multiple Myeloma - metabolism

Principal Component Analysis

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Title: Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma
Creators: C Ludwig - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
D S Williams - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
DAVID BARTLETT
S Essex - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
G McNee - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
J Allwood - School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK
E Jewell - School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK
A Barkhuisen - Department of Haematology, The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK
H Parry - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
S Anandram - Department of Haematology, The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK
P Nicolson - Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK
C Gardener - Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK
F Seymour - Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK
S Basu - Department of Haematology, The Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK
Warwick B. Dunn - School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK
P A H Moss - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
G Pratt - Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK
D A Tennant - School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
Publication Details: Blood cancer journal (New York), Vol.5(10), e359
Date published: 16/10/2015
Identifiers: 99620862702346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma

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