Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

JH Moffitt; BA Fielding; R Evershed; R Berstan; JM Currie; A Clark

doi:10.1007/s00125-005-1861-9

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Journal article

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

JH Moffitt, BA Fielding, R Evershed, R Berstan, JM Currie and A Clark

DIABETOLOGIA, Vol.48(9), pp.1819-1829

01/09/2005

DOI: https://doi.org/10.1007/s00125-005-1861-9

Abstract

Science & Technology

Life Sciences & Biomedicine

Endocrinology & Metabolism

ENDOCRINOLOGY & METABOLISM

beta cell

ER stress

INS1

insulin

lipotoxicity

oleate

palmitate

phospholipid

triglyceride

tripalmitin

FREE FATTY-ACIDS

STIMULATED INSULIN-SECRETION

LONG-TERM EXPOSURE

ENDOPLASMIC-RETICULUM STRESS

HORMONE-SENSITIVE LIPASE

RAT PANCREATIC-ISLETS

FACTOR-KAPPA-B

HIGH GLUCOSE

TRIGLYCERIDE ACCUMULATION

UNCOUPLING PROTEIN-2

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Title: Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro
Creators: JH Moffitt
BA Fielding
R Evershed
R Berstan
JM Currie
A Clark
Publication Details: DIABETOLOGIA, Vol.48(9), pp.1819-1829
Publisher: SPRINGER
Date published: 01/09/2005
Date submitted: 17/05/2017
Identifiers: 99513284302346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

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