Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates

GC Uguru; C Milne; M Borg; F Flett; CP Smith; J Micklefield

doi:10.1021/ja048778y

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Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates

Journal article

Peer reviewed

Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates

GC Uguru, C Milne, M Borg, F Flett, CP Smith and J Micklefield

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.126(16), pp.5032-5033

28/04/2004

DOI: https://doi.org/10.1021/ja048778y

Abstract

Science & Technology

Physical Sciences

Chemistry

Multidisciplinary

Chemistry

CHEMISTRY

MULTIDISCIPLINARY

STREPTOMYCES-COELICOLOR

II THIOESTERASES

CONFERRING CODE

RATIONAL DESIGN

SYNTHETASES

BIOSYNTHESIS

ANTIBIOTICS

SELECTIVITY

PRODUCTS

MODULE

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Title: Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates
Creators: GC Uguru
C Milne
M Borg
F Flett
CP Smith
J Micklefield
Publication Details: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol.126(16), pp.5032-5033
Publisher: AMER CHEMICAL SOC
Date published: 28/04/2004
Date submitted: 12/02/2012
Identifiers: 99510938102346
Academic Unit: University of Surrey
Language: English
Resource Type: Journal article

Active-site modifications of adenylation domains lead to hydrolysis of upstream nonribosomal peptidyl thioester intermediates

Abstract

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