A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

L Horsley; J Cummings; M Middleton; T Ward; A Backen; A Clamp; M Dawson; H Farmer; N Fisher; G Halbert; S Halford; A Harris; J Hasan; P Hogg; G Kumaran; R Little; GJM Parker; P Potter; M Saunders; C Roberts; D Shaw; N Smith; J Smythe; A Taylor; H Turner; Y Watson; C Dive; GC Jayson

doi:10.1007/s00280-013-2320-9

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A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

L Horsley, J Cummings, M Middleton, T Ward, A Backen, A Clamp, M Dawson, H Farmer, N Fisher, G Halbert, …

CANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol.72(6), pp.1343-1352

01/12/2013

DOI: https://doi.org/10.1007/s00280-013-2320-9

Abstract

Science & Technology

Life Sciences & Biomedicine

Oncology

Pharmacology & Pharmacy

ONCOLOGY

PHARMACOLOGY & PHARMACY

Phase 1

GSAO

Novel arsenic compound

Clinical trial

DCE-MRI

ACUTE PROMYELOCYTIC LEUKEMIA

APOPTOSIS PROTEIN XIAP

X-LINKED INHIBITOR

ARSENIC TRIOXIDE

CLINICAL-EFFICACY

ANGIOGENESIS INHIBITOR

METABOLISM INHIBITORS

CANCER-THERAPY

CELL-DEATH

VALIDATION

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Title: A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
Creators: L Horsley
J Cummings
M Middleton
T Ward
A Backen
A Clamp
M Dawson
H Farmer
N Fisher
G Halbert
S Halford
A Harris
J Hasan
P Hogg
G Kumaran
R Little
GJM Parker
P Potter
M Saunders
C Roberts
D Shaw
N Smith
J Smythe
A Taylor
H Turner
Y Watson
C Dive
GC Jayson
Publication Details: CANCER CHEMOTHERAPY AND PHARMACOLOGY, Vol.72(6), pp.1343-1352
Publisher: SPRINGER
Date published: 01/12/2013
Date submitted: 17/05/2017
Identifiers: 99513080702346
Academic Unit: University of Surrey; Department of Mechanical Engineering Sciences
Language: English
Resource Type: Journal article

A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours

Abstract

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