A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Shweta Ramdas; Jonathan Judd; Sarah E. Graham; Stavroula Kanoni; Yuxuan Wang; Ida Surakka; Brandon Wenz; Shoa L. Clarke; Alessandra Chesi; Andrew Wells; Konain Fatima Bhatti; Sailaja Vedantam; Thomas W. Winkler; Adam E. Locke; Eirini Marouli; Greg J.M. Zajac; Kuan-Han H. Wu; Ioanna Ntalla; Qin Hui; Derek Klarin; Austin T. Hilliard; Zeyuan Wang; Chao Xue; Gudmar Thorleifsson; Anna Helgadottir; Daniel F. Gudbjartsson; Hilma Holm; Isleifur Olafsson; Mi Yeong Hwang; Sohee Han; Masato Akiyama; Saori Sakaue; Chikashi Terao; Masahiro Kanai; Wei Zhou; Ben M. Brumpton; Humaira Rasheed; Aki S. Havulinna; Yogasudha Veturi; Jennifer Allen Pacheco; Elisabeth A. Rosenthal; Todd Lingren; QiPing Feng; Iftikhar J. Kullo; Akira Narita; Jun Takayama; Hilary C. Martin; Karen A. Hunt; Bhavi Trivedi; Jeffrey Haessler; Franco Giulianini; Yuki Bradford; Jason E. Miller; Archie Campbell; Kuang Lin; Iona Y. Millwood; Asif Rasheed; George Hindy; Jessica D. Faul; Wei Zhao; David R. Weir; Constance Turman; Hongyan Huang; Mariaelisa Graff; Ananyo Choudhury; Dhriti Sengupta; Anubha Mahajan; Michael R. Brown; Weihua Zhang; Ketian Yu; Ellen M. Schmidt; Anita Pandit; Stefan Gustafsson; Xianyong Yin; Jian’an Luan; Jing-Hua Zhao; Fumihiko Matsuda; Hye-Mi Jang; Kyungheon Yoon; Carolina Medina-Gomez; Achilleas Pitsillides; Jouke Jan Hottenga; Andrew R. Wood; Yingji Ji; Zishan Gao; Simon Haworth; Ruth E. Mitchell; Jin Fang Chai; Mette Aadahl; Anne A. Bjerregaard; Jie Yao; Ani Manichaikul; Wen-Jane Lee; Chao Agnes Hsiung; Helen R. Warren; Julia Ramirez; Jette Bork-Jensen; Line L. Kårhus; Anuj Goel; Maria Sabater-Lleal; Raymond Noordam; Pala Mauro; Floris Matteo; Aaron F. McDaid; Pedro Marques-Vidal; Matthias Wielscher; Stella Trompet; Naveed Sattar; Line T. Møllehave; Matthias Munz; Lingyao Zeng; Jianfeng Huang; Bin Yang; Alaitz Poveda; Azra Kurbasic; Sebastian Schönherr; Lukas Forer; Markus Scholz; Tessel E. Galesloot; Jonathan P. Bradfield; Sanni E. Ruotsalainen; E. Warwick Daw; Joseph M. Zmuda; Jonathan S. Mitchell; Christian Fuchsberger; Henry Christensen; Jennifer A. Brody; Phuong Le; Mary F. Feitosa; Mary K. Wojczynski; Daiane Hemerich; Michael Preuss; Massimo Mangino; Paraskevi Christofidou; Niek Verweij; Jan W. Benjamins; Jorgen Engmann; Tsao L. Noah; Anurag Verma; Roderick C. Slieker; Ken Sin Lo; Nuno R. Zilhao; Marcus E. Kleber; Graciela E. Delgado; Shaofeng Huo; Daisuke D. Ikeda; Hiroyuki Iha; Jian Yang; Jun Liu; Ayşe Demirkan; Hampton L. Leonard; Jonathan Marten; Carina Emmel; Börge Schmidt; Laura J. Smyth; Marisa Cañadas-Garre; Chaolong Wang; Masahiro Nakatochi; Andrew Wong; Nina Hutri-Kähönen; Xueling Sim; Rui Xia; Alicia Huerta-Chagoya; Juan Carlos Fernandez-Lopez; Valeriya Lyssenko; Suraj S. Nongmaithem; Alagu Sankareswaran; Marguerite R. Irvin; Christopher Oldmeadow; Han-Na Kim; Seungho Ryu; Paul R.H.J. Timmers; Liubov Arbeeva; Rajkumar Dorajoo; Leslie A. Lange; Gauri Prasad; Laura Lorés-Motta; Marc Pauper; Jirong Long; Xiaohui Li; Elizabeth Theusch; Fumihiko Takeuchi; Cassandra N. Spracklen; Anu Loukola; Sailalitha Bollepalli; Sophie C. Warner; Ya Xing Wang; Wen B. Wei; Teresa Nutile; Daniela Ruggiero; Yun Ju Sung; Shufeng Chen; Fangchao Liu; Jingyun Yang; Katherine A. Kentistou; Bernhard Banas; Anna Morgan; Karina Meidtner; Lawrence F. Bielak; Jennifer A. Smith; Prashantha Hebbar; Aliki-Eleni Farmaki; Edith Hofer; Maoxuan Lin; Maria Pina Concas; Simona Vaccargiu; Peter J. van der Most; Niina Pitkänen; Brian E. Cade; Sander W. van der Laan; Kumaraswamy Naidu Chitrala; Stefan Weiss; Amy R. Bentley; Ayo P. Doumatey; Adebowale A. Adeyemo; Jong Young Lee; Eva R.B. Petersen; Aneta A. Nielsen; Hyeok Sun Choi; Maria Nethander; Sandra Freitag-Wolf; Lorraine Southam; Nigel W. Rayner; Carol A. Wang; Shih-Yi Lin; Jun-Sing Wang; Christian Couture; Leo-Pekka Lyytikäinen; Kjell Nikus; Gabriel Cuellar-Partida; Henrik Vestergaard; Bertha Hidalgo; Olga Giannakopoulou; Qiuyin Cai; Morgan O. Obura; Jessica van Setten; Karen Y. He; Hua Tang; Natalie Terzikhan; Jae Hun Shin; Rebecca D. Jackson; Alexander P. Reiner; Lisa Warsinger Martin; Zhengming Chen; Liming Li; Takahisa Kawaguchi; Joachim Thiery; Joshua C. Bis; Lenore J. Launer; Huaixing Li; Mike A. Nalls; Olli T. Raitakari; Sahoko Ichihara; Sarah H. Wild; Christopher P. Nelson; Harry Campbell; Susanne Jäger; Toru Nabika; Fahd Al-Mulla; Harri Niinikoski; Peter S. Braund; Ivana Kolcic; Peter Kovacs; Tota Giardoglou; Tomohiro Katsuya; Dominique de Kleijn; Gert J. de Borst; Eung Kweon Kim; Hieab H.H. Adams; M. Arfan Ikram; Xiaofeng Zhu; Folkert W. Asselbergs; Adriaan O. Kraaijeveld; Joline W.J. Beulens; Xiao-Ou Shu; Loukianos S. Rallidis; Oluf Pedersen; Torben Hansen; Paul Mitchell; Alex W. Hewitt; Mika Kähönen; Louis Pérusse; Claude Bouchard; Anke Tönjes; Yii-Der Ida Chen; Craig E. Pennell; Trevor A. Mori; Wolfgang Lieb; Andre Franke; Claes Ohlsson; Dan Mellström; Yoon Shin Cho; Hyejin Lee; Jian-Min Yuan; Woon-Puay Koh; Sang Youl Rhee; Jeong-Taek Woo; Iris M. Heid; Klaus J. Stark; Martina E. Zimmermann; Henry Völzke; Georg Homuth; Michele K. Evans; Alan B. Zonderman; Ozren Polasek; Gerard Pasterkamp; Imo E. Hoefer; Susan Redline; Katja Pahkala; Albertine J. Oldehinkel; Harold Snieder; Ginevra Biino; Reinhold Schmidt; Helena Schmidt; Stefania Bandinelli; George Dedoussis; Thangavel Alphonse Thanaraj; Patricia A. Peyser; Norihiro Kato; Matthias B. Schulze; Giorgia Girotto; Carsten A. Böger; Bettina Jung; Peter K. Joshi; David A. Bennett; Philip L. De Jager; Xiangfeng Lu; Vasiliki Mamakou; Morris Brown; Mark J. Caulfield; Patricia B. Munroe; Xiuqing Guo; Marina Ciullo; Jost B. Jonas; Nilesh J. Samani; Jaakko Kaprio; Päivi Pajukanta; Teresa Tusié-Luna; Carlos A. Aguilar-Salinas; Linda S. Adair; Sonny Augustin Bechayda; H. Janaka de Silva; Ananda R. Wickremasinghe; Ronald M. Krauss; Jer-Yuarn Wu; Wei Zheng; Anneke I. den Hollander; Dwaipayan Bharadwaj; Adolfo Correa; James G. Wilson; Lars Lind; Chew-Kiat Heng; Amanda E. Nelson; Yvonne M. Golightly; James F. Wilson; Brenda Penninx; Hyung-Lae Kim; John Attia; Rodney J. Scott; D.C. Rao; Donna K. Arnett; Mark Walker; Laura J. Scott; Heikki A. Koistinen; Giriraj R. Chandak; Josep M. Mercader; Clicerio Gonzalez Villalpando; Lorena Orozco; Myriam Fornage; E. Shyong Tai; Rob M. van Dam; Terho Lehtimäki; Nish Chaturvedi; Mitsuhiro Yokota; Jianjun Liu; Dermot F. Reilly; Amy Jayne McKnight; Frank Kee; Karl-Heinz Jöckel; Mark I. McCarthy; Colin N.A. Palmer; Veronique Vitart; Caroline Hayward; Eleanor Simonsick; Cornelia M. van Duijn; Zi-Bing Jin; Fan Lu; Haretsugu Hishigaki; Xu Lin; Winfried März; Vilmundur Gudnason; Jean-Claude Tardif; Guillaume Lettre; Leen M. t Hart; Petra J.M. Elders; Daniel J. Rader; Scott M. Damrauer; Meena Kumari; Mika Kivimaki; Pim van der Harst; Tim D. Spector; Ruth J.F. Loos; Michael A. Province; Esteban J. Parra; Miguel Cruz; Bruce M. Psaty; Ivan Brandslund; Peter P. Pramstaller; Charles N. Rotimi; Kaare Christensen; Samuli Ripatti; Elisabeth Widén; Hakon Hakonarson; Struan F.A. Grant; Lambertus Kiemeney; Jacqueline de Graaf; Markus Loeffler; Florian Kronenberg; Dongfeng Gu; Jeanette Erdmann; Heribert Schunkert; Paul W. Franks; Allan Linneberg; J. Wouter Jukema; Amit V. Khera; Minna Männikkö; Marjo-Riitta Jarvelin; Zoltan Kutalik; Cucca Francesco; Dennis O. Mook-Kanamori; Ko Willems van Dijk; Hugh Watkins; David P. Strachan; Niels Grarup; Peter Sever; Neil Poulter; Wayne Huey-Herng Sheu; Jerome I. Rotter; Thomas M. Dantoft; Fredrik Karpe; Matt J. Neville; Nicholas J. Timpson; Ching-Yu Cheng; Tien-Yin Wong; Chiea Chuen Khor; Hengtong Li; Charumathi Sabanayagam; Annette Peters; Christian Gieger; Andrew T. Hattersley; Nancy L. Pedersen; Patrik K.E. Magnusson; Dorret I. Boomsma; Eco J.C. de Geus; L. Adrienne Cupples; Joyce B.J. van Meurs; Arfan Ikram; Mohsen Ghanbari; Penny Gordon-Larsen; Wei Huang; Young Jin Kim; Yasuharu Tabara; Nicholas J. Wareham; Claudia Langenberg; Eleftheria Zeggini; Jaakko Tuomilehto; Johanna Kuusisto; Markku Laakso; Erik Ingelsson; Goncalo Abecasis; John C. Chambers; Jaspal S. Kooner; Paul S. de Vries; Alanna C. Morrison; Scott Hazelhurst; Michèle Ramsay; Kari E. North; Martha Daviglus; Peter Kraft; Nicholas G. Martin; John B. Whitfield; Shahid Abbas; Danish Saleheen; Robin G. Walters; Michael V. Holmes; Corri Black; Blair H. Smith; Aris Baras; Anne E. Justice; Julie E. Buring; Paul M. Ridker; Daniel I. Chasman; Charles Kooperberg; Gen Tamiya; Masayuki Yamamoto; David A. van Heel; Richard C. Trembath; Wei-Qi Wei; Gail P. Jarvik; Bahram Namjou; M. Geoffrey Hayes; Marylyn D. Ritchie; Pekka Jousilahti; Veikko Salomaa; Kristian Hveem; Bjørn Olav Åsvold; Michiaki Kubo; Yoichiro Kamatani; Yukinori Okada; Yoshinori Murakami; Bong-Jo Kim; Unnur Thorsteinsdottir; Kari Stefansson; Jifeng Zhang; Y. Eugene Chen; Yuk-Lam Ho; Julie A. Lynch; Philip S. Tsao; Kyong-Mi Chang; Kelly Cho; Christopher J. O'Donnell; John M. Gaziano; Peter Wilson; Karen L. Mohlke; Timothy M. Frayling; Joel N. Hirschhorn; Sekar Kathiresan; Michael Boehnke; Struan Grant; Pradeep Natarajan; Yan V. Sun; Andrew P. Morris; Panos Deloukas; Gina Peloso; Themistocles L. Assimes; Cristen J. Willer; Xiang Zhu; Christopher D. Brown; Global Lipids Genetics Consortium

doi:10.1016/j.ajhg.2022.06.012

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A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Journal article

Open access

Peer reviewed

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Shweta Ramdas, Jonathan Judd, Sarah E. Graham, Stavroula Kanoni, Yuxuan Wang, Ida Surakka, Brandon Wenz, Shoa L. Clarke, Alessandra Chesi, Andrew Wells, …

American journal of human genetics, Vol.109(8), pp.1366-1387

04/08/2022

DOI: https://doi.org/10.1016/j.ajhg.2022.06.012

PMID: 35931049

Abstract

complex traits

fine-mapping

functional genomics

lipid biology

post-GWAS

regulatory mechanism

variant prioritization

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology. In this study, we present a multi-layer framework to combine the largest multi-ancestry GWAS to date on lipid levels with both transcriptomic and epigenomic datasets to prioritize regulatory variants, effector genes, cell types, and tissues with strong functional relevance to lipid biology.

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Title: A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Creators: Shweta Ramdas - University of Pennsylvania
Jonathan Judd - Stanford University
Sarah E. Graham - University of Michigan–Ann Arbor
Stavroula Kanoni - Queen Mary University of London
Yuxuan Wang - Boston University
Ida Surakka - University of Michigan–Ann Arbor
Brandon Wenz - University of Pennsylvania
Shoa L. Clarke - Stanford University
Alessandra Chesi - University of Pennsylvania
Andrew Wells - University of Pennsylvania
Konain Fatima Bhatti - William Harvey Research Institute
Sailaja Vedantam - Boston Children's Hospital
Thomas W. Winkler - University of Regensburg
Adam E. Locke - James S. McDonnell Foundation
Eirini Marouli - William Harvey Research Institute
Greg J.M. Zajac - University of Michigan–Ann Arbor
Kuan-Han H. Wu - University of Michigan–Ann Arbor
Ioanna Ntalla - Queen Mary University of London
Qin Hui - Emory University
Derek Klarin - Malcom Randall VA Medical Center
Austin T. Hilliard - VA Palo Alto Health Care System
Zeyuan Wang - Emory University
Chao Xue - University of Michigan–Ann Arbor
Gudmar Thorleifsson - deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland
Anna Helgadottir - deCODE Genetics
Daniel F. Gudbjartsson - deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland
Hilma Holm - deCODE Genetics
Isleifur Olafsson - National University Hospital of Iceland
Mi Yeong Hwang - Korea National Institute of Health
Sohee Han - Korea National Institute of Health
Masato Akiyama - RIKEN Center for Integrative Medical Sciences
Saori Sakaue - The University of Tokyo
Chikashi Terao - RIKEN Center for Integrative Medical Sciences
Masahiro Kanai - Harvard University
Wei Zhou - University of Michigan–Ann Arbor
Ben M. Brumpton - Norwegian University of Science and Technology
Humaira Rasheed - Norwegian University of Science and Technology
Aki S. Havulinna - Finnish Institute for Health and Welfare
Yogasudha Veturi - University of Pennsylvania
Jennifer Allen Pacheco - Northwestern University
Elisabeth A. Rosenthal - University of Washington Medical Center
Todd Lingren - Cincinnati Children's Hospital Medical Center
QiPing Feng - Vanderbilt University Medical Center
Iftikhar J. Kullo - Mayo Clinic
Akira Narita - Tohoku Medical Megabank Organization
Jun Takayama - Tohoku Medical Megabank Organization
Hilary C. Martin - Wellcome Sanger Institute
Karen A. Hunt - Queen Mary University of London
Bhavi Trivedi - Queen Mary University of London
Jeffrey Haessler - Fred Hutch Cancer Center
Franco Giulianini - Brigham and Women's Hospital
Yuki Bradford - University of Pennsylvania
Jason E. Miller - University of Pennsylvania
Archie Campbell - University of Edinburgh
Kuang Lin - University of Oxford
Iona Y. Millwood - Medical Research Council
Asif Rasheed - Center for Non-Communicable Diseases
George Hindy - Qatar University
Jessica D. Faul - University of Michigan–Ann Arbor
Wei Zhao - University of Michigan–Ann Arbor
David R. Weir - University of Michigan–Ann Arbor
Constance Turman - The Huntington Library, Art Museum, and Botanical Gardens
Hongyan Huang - The Huntington Library, Art Museum, and Botanical Gardens
Mariaelisa Graff - University of North Carolina at Chapel Hill
Ananyo Choudhury - University of the Witwatersrand
Dhriti Sengupta - University of the Witwatersrand
Anubha Mahajan - University of Oxford
Michael R. Brown - The University of Texas Health Science Center at Houston
Weihua Zhang - London North West Healthcare NHS Trust
Ketian Yu - University of Michigan–Ann Arbor
Ellen M. Schmidt - University of Michigan–Ann Arbor
Anita Pandit - University of Michigan–Ann Arbor
Stefan Gustafsson - Uppsala University
Xianyong Yin - University of Michigan–Ann Arbor
Jian’an Luan - MRC Epidemiology Unit
Jing-Hua Zhao - University of Cambridge
Fumihiko Matsuda - Kyoto University
Hye-Mi Jang - Korea National Institute of Health
Kyungheon Yoon - Korea National Institute of Health
Carolina Medina-Gomez - Erasmus MC
Achilleas Pitsillides - Boston University
Jouke Jan Hottenga - Amsterdam University Medical Centers
Andrew R. Wood - University of Exeter
Yingji Ji - University of Exeter
Zishan Gao - Helmholtz Zentrum München
Simon Haworth - University Of Bristol Dental Hospital
Ruth E. Mitchell - University of Bristol
Jin Fang Chai - National University Health System
Mette Aadahl - University of Copenhagen
Anne A. Bjerregaard - Frederiksberg Hospital
Jie Yao - Harbor–UCLA Medical Center
Ani Manichaikul - University of Virginia
Wen-Jane Lee
Chao Agnes Hsiung - National Health Research Institutes
Helen R. Warren - Queen Mary University of London
Julia Ramirez - William Harvey Research Institute
Jette Bork-Jensen - Novo Nordisk Foundation
Line L. Kårhus - Frederiksberg Hospital
Anuj Goel - University of Oxford
Maria Sabater-Lleal - Genomics
Raymond Noordam - Leiden University Medical Center
Pala Mauro - Institute of Genetic and Biomedical Research
Floris Matteo - GeneTiCA
Aaron F. McDaid - SIB Swiss Institute of Bioinformatics
Pedro Marques-Vidal - University of Lausanne
Matthias Wielscher - Imperial College London
Stella Trompet - Leiden University Medical Center
Naveed Sattar - Faculty
Line T. Møllehave - Frederiksberg Hospital
Matthias Munz - Charité - Universitätsmedizin Berlin
Lingyao Zeng - Deutsches Herzzentrum München
Jianfeng Huang - Chinese Academy of Medical Sciences & Peking Union Medical College
Bin Yang - Chinese Academy of Medical Sciences & Peking Union Medical College
Alaitz Poveda - Lund University
Azra Kurbasic - Lund University
Sebastian Schönherr - Innsbruck Medical University
Lukas Forer - Innsbruck Medical University
Markus Scholz - Leipzig University
Tessel E. Galesloot - Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands
Jonathan P. Bradfield - Praevium Research
Sanni E. Ruotsalainen - Institute for Molecular Medicine Finland
E. Warwick Daw - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Joseph M. Zmuda - University of Pittsburgh
Jonathan S. Mitchell - Institute for Biomedicine
Christian Fuchsberger - Eurac Research
Henry Christensen - Lillebaelt Hospital
Jennifer A. Brody - University of Washington
Phuong Le - University of Toronto
Mary F. Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Mary K. Wojczynski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Daiane Hemerich - Icahn School of Medicine at Mount Sinai
Michael Preuss - Icahn School of Medicine at Mount Sinai
Massimo Mangino - Guy's and St Thomas' NHS Foundation Trust
Paraskevi Christofidou - King's College London
Niek Verweij - University Medical Center Groningen
Jan W. Benjamins - University Medical Center Groningen
Jorgen Engmann - University College London
Tsao L. Noah - University of Pennsylvania
Anurag Verma - University of Pennsylvania
Roderick C. Slieker - Leiden University Medical Center
Ken Sin Lo - Montreal Heart Institute
Nuno R. Zilhao - Icelandic Heart Association
Marcus E. Kleber - University Medical Centre Mannheim
Graciela E. Delgado - University Medical Centre Mannheim
Shaofeng Huo - Shanghai Institute of Nutrition and Health
Daisuke D. Ikeda - Otsuka
Hiroyuki Iha - Otsuka
Jian Yang - Westlake University
Jun Liu - University of Oxford
Ayşe Demirkan - University of Surrey
Hampton L. Leonard - National Institute on Aging
Jonathan Marten - University of Edinburgh
Carina Emmel - University of Duisburg-Essen
Börge Schmidt - University of Duisburg-Essen
Laura J. Smyth - Queen's University Belfast
Marisa Cañadas-Garre - Instituto de Investigación Biosanitaria de Granada
Chaolong Wang - Genome Institute of Singapore
Masahiro Nakatochi - Nagoya University
Andrew Wong - University of Alabama at Birmingham
Nina Hutri-Kähönen - Tampere University
Xueling Sim - National University Health System
Rui Xia - Brown Foundation
Alicia Huerta-Chagoya - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Juan Carlos Fernandez-Lopez - National Institute of Genomic Medicine
Valeriya Lyssenko - Lund University
Suraj S. Nongmaithem - Centre for Cellular and Molecular Biology
Alagu Sankareswaran - Centre for Cellular and Molecular Biology
Marguerite R. Irvin - University of Alabama at Birmingham
Christopher Oldmeadow - Hunter Medical Research Institute
Han-Na Kim - Sungkyunkwan University
Seungho Ryu - Kangbuk Samsung Hospital
Paul R.H.J. Timmers - University of Edinburgh
Liubov Arbeeva - University of North Carolina at Chapel Hill
Rajkumar Dorajoo - Duke-NUS Medical School
Leslie A. Lange - University of Colorado Anschutz Medical Campus
Gauri Prasad - Academy of Scientific and Innovative Research
Laura Lorés-Motta - Radboud University Nijmegen
Marc Pauper - Radboud University Nijmegen
Jirong Long - Vanderbilt University Medical Center
Xiaohui Li - UCLA Medical Center
Elizabeth Theusch - University of California, San Francisco
Fumihiko Takeuchi - National Center for Global Health and Medicine
Cassandra N. Spracklen - University of Massachusetts Amherst
Anu Loukola - University of Helsinki
Sailalitha Bollepalli - Institute for Molecular Medicine Finland
Sophie C. Warner - University of Leicester
Ya Xing Wang - Capital Medical University
Wen B. Wei - Capital Medical University
Teresa Nutile - Institute of Genetics and Biophysics
Daniela Ruggiero - Istituto Neurologico Mediterraneo
Yun Ju Sung - Washington University in St. Louis
Shufeng Chen - Chinese Academy of Medical Sciences & Peking Union Medical College
Fangchao Liu - Chinese Academy of Medical Sciences & Peking Union Medical College
Jingyun Yang - Rush University Medical Center
Katherine A. Kentistou - University of Edinburgh
Bernhard Banas - University Hospital Regensburg
Anna Morgan - IRCCS Materno Infantile Burlo Garofolo
Karina Meidtner - German Institute of Human Nutrition
Lawrence F. Bielak - University of Michigan–Ann Arbor
Jennifer A. Smith - University of Michigan–Ann Arbor
Prashantha Hebbar - Dasman Diabetes Institute
Aliki-Eleni Farmaki - Harokopio University of Athens
Edith Hofer - Medical University of Graz
Maoxuan Lin - Massachusetts General Hospital
Maria Pina Concas - IRCCS Materno Infantile Burlo Garofolo
Simona Vaccargiu - Institute of Genetic and Biomedical Research
Peter J. van der Most - University Medical Center Groningen
Niina Pitkänen - University of Turku
Brian E. Cade - Brigham and Women's Hospital
Sander W. van der Laan - Utrecht University
Kumaraswamy Naidu Chitrala - National Institute on Aging
Stefan Weiss - University of Greifswald
Amy R. Bentley - National Human Genome Research Institute
Ayo P. Doumatey - National Human Genome Research Institute
Adebowale A. Adeyemo - National Human Genome Research Institute
Jong Young Lee - Swedish Institute
Eva R.B. Petersen - Sygehus Sønderjylland
Aneta A. Nielsen - Lillebaelt Hospital
Hyeok Sun Choi - Hallym University
Maria Nethander - University of Gothenburg
Sandra Freitag-Wolf - Kiel University
Lorraine Southam - Helmholtz Zentrum München
Nigel W. Rayner - Oxford Centre for Diabetes, Endocrinology and Metabolism
Carol A. Wang - University of Newcastle Australia
Shih-Yi Lin - National Defense Medical Center
Jun-Sing Wang - Taichung Veterans General Hospital
Christian Couture - Université Laval
Leo-Pekka Lyytikäinen - Tampere University
Kjell Nikus - Tampere University Hospital
Gabriel Cuellar-Partida - Translational Research Institute
Henrik Vestergaard - Novo Nordisk Foundation
Bertha Hidalgo - University of Alabama at Birmingham
Olga Giannakopoulou - William Harvey Research Institute
Qiuyin Cai - Vanderbilt University Medical Center
Morgan O. Obura - Public Health Service of Amsterdam
Jessica van Setten - University Medical Center Utrecht
Karen Y. He - Case Western Reserve University
Hua Tang - Stanford University
Natalie Terzikhan - Erasmus MC
Jae Hun Shin - Hallym University
Rebecca D. Jackson - The Ohio State University
Alexander P. Reiner - University of Washington
Lisa Warsinger Martin - George Washington University
Zhengming Chen - Medical Research Council
Liming Li - Peking University
Takahisa Kawaguchi - Kyoto University
Joachim Thiery - University Hospital Leipzig
Joshua C. Bis - University of Washington
Lenore J. Launer - National Institute on Aging
Huaixing Li - Shanghai Institute of Nutrition and Health
Mike A. Nalls - National Institute on Aging
Olli T. Raitakari - University of Turku
Sahoko Ichihara - Jichi Medical University
Sarah H. Wild - University of Edinburgh
Christopher P. Nelson - University of Leicester
Harry Campbell - University of Edinburgh
Susanne Jäger - German Institute of Human Nutrition
Toru Nabika - Shimane University
Fahd Al-Mulla - Dasman Diabetes Institute
Harri Niinikoski - University of Turku
Peter S. Braund - NIHR Leicester Biomedical Research Centre
Ivana Kolcic - University of Split
Peter Kovacs - Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstr. 21, 04103 Leipzig, Germany
Tota Giardoglou - Harokopio University of Athens
Tomohiro Katsuya - Osaka University
Dominique de Kleijn - University Medical Center Utrecht
Gert J. de Borst - Utrecht University
Eung Kweon Kim - Yonsei University
Hieab H.H. Adams - Erasmus MC
M. Arfan Ikram - Erasmus MC
Xiaofeng Zhu - Case Western Reserve University
Folkert W. Asselbergs - University Medical Center Utrecht
Adriaan O. Kraaijeveld - University Medical Center Utrecht
Joline W.J. Beulens - Amsterdam University Medical Centers
Xiao-Ou Shu - Vanderbilt University Medical Center
Loukianos S. Rallidis - National and Kapodistrian University of Athens
Oluf Pedersen - University of Copenhagen
Torben Hansen - University of Copenhagen
Paul Mitchell - Westmead Institute
Alex W. Hewitt - University of Tasmania
Mika Kähönen - Tampere University
Louis Pérusse - Université Laval
Claude Bouchard - Pennington Biomedical Research Center
Anke Tönjes - Medical Department III – Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Liebigstr. 21, 04103 Leipzig, Germany
Yii-Der Ida Chen - Harbor–UCLA Medical Center
Craig E. Pennell - University of Newcastle Australia
Trevor A. Mori - University of Western Australia
Wolfgang Lieb - Kiel University
Andre Franke - Kiel University
Claes Ohlsson - Sahlgrenska University Hospital
Dan Mellström - University of Gothenburg
Yoon Shin Cho - Hallym University
Hyejin Lee - Ewha Womans University
Jian-Min Yuan - University of Pittsburgh
Woon-Puay Koh - National University of Singapore
Sang Youl Rhee - Kyung Hee University
Jeong-Taek Woo - Kyung Hee University
Iris M. Heid - University of Regensburg
Klaus J. Stark - University of Regensburg
Martina E. Zimmermann - University of Regensburg
Henry Völzke - Greifswald University Hospital
Georg Homuth - Greifswald University Hospital
Michele K. Evans - National Institute on Aging
Alan B. Zonderman - National Institute on Aging
Ozren Polasek - University of Split
Gerard Pasterkamp - Utrecht University
Imo E. Hoefer - Utrecht University
Susan Redline - Brigham and Women's Hospital
Katja Pahkala - University of Turku
Albertine J. Oldehinkel - University Medical Center Groningen
Harold Snieder - University Medical Center Groningen
Ginevra Biino - National Research Council
Reinhold Schmidt - Medical University of Graz
Helena Schmidt - Medical University of Graz
Stefania Bandinelli - Azienda Usl Toscana Centro
George Dedoussis - Harokopio University of Athens
Thangavel Alphonse Thanaraj - Dasman Diabetes Institute
Patricia A. Peyser - University of Michigan–Ann Arbor
Norihiro Kato - National Center for Global Health and Medicine
Matthias B. Schulze - German Institute of Human Nutrition
Giorgia Girotto - University of Trieste
Carsten A. Böger - Löwenstein Medical
Bettina Jung - Löwenstein Medical
Peter K. Joshi - University of Edinburgh
David A. Bennett - Rush University Medical Center
Philip L. De Jager - Broad Institute
Xiangfeng Lu - Chinese Academy of Medical Sciences & Peking Union Medical College
Vasiliki Mamakou - National and Kapodistrian University of Athens
Morris Brown - Queen Mary University of London
Mark J. Caulfield - Queen Mary University of London
Patricia B. Munroe - Queen Mary University of London
Xiuqing Guo - Harbor–UCLA Medical Center
Marina Ciullo - Istituto Neurologico Mediterraneo
Jost B. Jonas - Institute of Molecular and Clinical Ophthalmology Basel
Nilesh J. Samani - University of Leicester
Jaakko Kaprio - University of Helsinki
Päivi Pajukanta - University of California, Los Angeles
Teresa Tusié-Luna - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Carlos A. Aguilar-Salinas - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Linda S. Adair - University of North Carolina at Chapel Hill
Sonny Augustin Bechayda - University of San Carlos
H. Janaka de Silva - University of Kelaniya
Ananda R. Wickremasinghe - University of Kelaniya
Ronald M. Krauss - Children’s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Jer-Yuarn Wu - Institute of Biomedical Sciences, Academia Sinica
Wei Zheng - Vanderbilt University Medical Center
Anneke I. den Hollander - Radboud University Nijmegen
Dwaipayan Bharadwaj - Academy of Scientific and Innovative Research
Adolfo Correa - University of Mississippi Medical Center
James G. Wilson - University of Mississippi Medical Center
Lars Lind - Uppsala University
Chew-Kiat Heng
Amanda E. Nelson - University of North Carolina at Chapel Hill
Yvonne M. Golightly - University of North Carolina at Chapel Hill
James F. Wilson - University of Edinburgh
Brenda Penninx - Vrije Universiteit Amsterdam
Hyung-Lae Kim - Ewha Womans University
John Attia - Hunter Medical Research Institute
Rodney J. Scott - Hunter Medical Research Institute
D.C. Rao - Washington University in St. Louis
Donna K. Arnett - University of Kentucky
Mark Walker - Newcastle University
Laura J. Scott - University of Michigan–Ann Arbor
Heikki A. Koistinen - Minerva Foundation
Giriraj R. Chandak - Centre for Cellular and Molecular Biology
Josep M. Mercader - Massachusetts General Hospital
Clicerio Gonzalez Villalpando - Instituto Nacional de Salud Pública
Lorena Orozco - National Institute of Genomic Medicine
Myriam Fornage - The University of Texas Health Science Center at Houston
E. Shyong Tai - National University Health System
Rob M. van Dam - National University Health System
Terho Lehtimäki - Tampere University
Nish Chaturvedi - MRC Unit for Lifelong Health and Ageing
Mitsuhiro Yokota - Kurume University
Jianjun Liu - Genome Institute of Singapore
Dermot F. Reilly - MSD
Amy Jayne McKnight - Queen's University Belfast
Frank Kee - Queen's University Belfast
Karl-Heinz Jöckel - University of Duisburg-Essen
Mark I. McCarthy - Wellcome Centre for Human Genetics
Colin N.A. Palmer - University of Dundee
Veronique Vitart - University of Edinburgh
Caroline Hayward - University of Edinburgh
Eleanor Simonsick - National Institute on Aging
Cornelia M. van Duijn - Erasmus MC
Zi-Bing Jin - Capital Medical University
Fan Lu - Wenzhou Medical University
Haretsugu Hishigaki - Otsuka
Xu Lin - Shanghai Institute of Nutrition and Health
Winfried März - Synlab
Vilmundur Gudnason - Icelandic Heart Association
Jean-Claude Tardif - Université de Montréal
Guillaume Lettre - Montreal Heart Institute
Leen M. t Hart - Amsterdam University Medical Centers
Petra J.M. Elders - Amsterdam University Medical Centers
Daniel J. Rader - University of Pennsylvania
Scott M. Damrauer - Philadelphia VA Medical Center
Meena Kumari - University of Essex
Mika Kivimaki - University College London
Pim van der Harst - University Medical Center Groningen
Tim D. Spector - King's College London
Ruth J.F. Loos - Icahn School of Medicine at Mount Sinai
Michael A. Province - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA
Esteban J. Parra - University of Toronto
Miguel Cruz - Centro Medico Nacional Siglo XXI
Bruce M. Psaty - University of Washington
Ivan Brandslund - Lillebaelt Hospital
Peter P. Pramstaller - Eurac Research
Charles N. Rotimi - National Human Genome Research Institute
Kaare Christensen - University of Southern Denmark
Samuli Ripatti - Institute for Molecular Medicine Finland
Elisabeth Widén - Institute for Molecular Medicine Finland
Hakon Hakonarson - Children's Hospital of Philadelphia
Struan F.A. Grant - Children's Hospital of Philadelphia
Lambertus Kiemeney - Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands
Jacqueline de Graaf - Radboud university medical center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands
Markus Loeffler - Leipzig University
Florian Kronenberg - Innsbruck Medical University
Dongfeng Gu - Southern University of Science and Technology
Jeanette Erdmann - Charité - Universitätsmedizin Berlin
Heribert Schunkert - Deutsches Herzzentrum München
Paul W. Franks - Lund University
Allan Linneberg - Center for Clinical Research and Prevention
J. Wouter Jukema - Netherlands Heart Institute
Amit V. Khera - Massachusetts General Hospital
Minna Männikkö - University of Oulu
Marjo-Riitta Jarvelin - Imperial College London
Zoltan Kutalik - University of Lausanne
Cucca Francesco - Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy
Dennis O. Mook-Kanamori - Leiden University Medical Center
Ko Willems van Dijk - Leiden University Medical Center
Hugh Watkins - University of Oxford
David P. Strachan - St George's, University of London
Niels Grarup - University of Copenhagen
Peter Sever - Imperial College London
Neil Poulter - Imperial College London
Wayne Huey-Herng Sheu
Jerome I. Rotter - Harbor–UCLA Medical Center
Thomas M. Dantoft - Frederiksberg Hospital
Fredrik Karpe - Oxford Centre for Diabetes, Endocrinology and Metabolism
Matt J. Neville - University of Oxford
Nicholas J. Timpson - University of Bristol
Ching-Yu Cheng - Duke-NUS Medical School
Tien-Yin Wong - Singapore Eye Research Institute
Chiea Chuen Khor - Genome Institute of Singapore
Hengtong Li - Singapore National Eye Center
Charumathi Sabanayagam - Duke-NUS Medical School
Annette Peters - German Center for Diabetes Research
Christian Gieger - Helmholtz Zentrum München
Andrew T. Hattersley - University of Exeter
Nancy L. Pedersen - Karolinska Institutet
Patrik K.E. Magnusson - Karolinska Institutet
Dorret I. Boomsma - Amsterdam UMC Location VUmc
Eco J.C. de Geus - Amsterdam UMC Location VUmc
L. Adrienne Cupples - Boston University
Joyce B.J. van Meurs - Erasmus MC
Arfan Ikram - Erasmus MC
Mohsen Ghanbari - Mashhad University of Medical Sciences
Penny Gordon-Larsen - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Wei Huang - Chinese National Human Genome Center
Young Jin Kim - Korea National Institute of Health
Yasuharu Tabara - Kyoto University
Nicholas J. Wareham - MRC Epidemiology Unit
Claudia Langenberg - University of Cambridge
Eleftheria Zeggini - Helmholtz Zentrum München
Jaakko Tuomilehto - King Abdulaziz University
Johanna Kuusisto - University of Eastern Finland
Markku Laakso - University of Eastern Finland
Erik Ingelsson - Stanford University
Goncalo Abecasis - University of Michigan–Ann Arbor
John C. Chambers - Imperial College London
Jaspal S. Kooner - Imperial College London
Paul S. de Vries - The University of Texas Health Science Center at Houston
Alanna C. Morrison - The University of Texas Health Science Center at Houston
Scott Hazelhurst - University of the Witwatersrand
Michèle Ramsay - University of the Witwatersrand
Kari E. North - University of North Carolina at Chapel Hill
Martha Daviglus - Office of Minority Health
Peter Kraft - Harvard University
Nicholas G. Martin - QIMR Berghofer Medical Research Institute
John B. Whitfield - QIMR Berghofer Medical Research Institute
Shahid Abbas - Center for Non-Communicable Diseases
Danish Saleheen - Columbia University Irving Medical Center
Robin G. Walters - Open Data Institute
Michael V. Holmes - Churchill Hospital
Corri Black - University of Aberdeen
Blair H. Smith - University of Dundee
Aris Baras - Regeneron
Anne E. Justice - Geisinger Health System
Julie E. Buring - Brigham and Women's Hospital
Paul M. Ridker - Brigham and Women's Hospital
Daniel I. Chasman - Brigham and Women's Hospital
Charles Kooperberg - Fred Hutch Cancer Center
Gen Tamiya - Tohoku Medical Megabank Organization
Masayuki Yamamoto - Tohoku Medical Megabank Organization
David A. van Heel - Queen Mary University of London
Richard C. Trembath - King's College London
Wei-Qi Wei - Vanderbilt University Medical Center
Gail P. Jarvik - University of Washington Medical Center
Bahram Namjou - Cincinnati Children's Hospital Medical Center
M. Geoffrey Hayes - Northwestern University
Marylyn D. Ritchie - University of Pennsylvania
Pekka Jousilahti - Finnish Institute for Health and Welfare
Veikko Salomaa - Finnish Institute for Health and Welfare
Kristian Hveem - Norwegian University of Science and Technology
Bjørn Olav Åsvold - Norwegian University of Science and Technology
Michiaki Kubo - RIKEN Center for Integrative Medical Sciences
Yoichiro Kamatani - RIKEN Center for Integrative Medical Sciences
Yukinori Okada - Osaka University
Yoshinori Murakami - The University of Tokyo
Bong-Jo Kim - Korea National Institute of Health
Unnur Thorsteinsdottir - deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland
Kari Stefansson - deCODE Genetics
Jifeng Zhang - University of Michigan–Ann Arbor
Y. Eugene Chen - University of Michigan–Ann Arbor
Yuk-Lam Ho - VA Boston Healthcare System
Julie A. Lynch - VA Salt Lake City Healthcare System
Philip S. Tsao - Stanford University
Kyong-Mi Chang - Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA
Kelly Cho - Brigham and Women's Hospital
Christopher J. O'Donnell - VA Boston Healthcare System
John M. Gaziano - VA Boston Healthcare System
Peter Wilson - Atlanta VA Health Care System
Karen L. Mohlke - University of North Carolina at Chapel Hill
Timothy M. Frayling - University of Exeter
Joel N. Hirschhorn - Broad Institute
Sekar Kathiresan - Massachusetts General Hospital
Michael Boehnke - University of Michigan–Ann Arbor
Struan Grant - University of Pennsylvania
Pradeep Natarajan - Massachusetts General Hospital
Yan V. Sun - Emory University
Andrew P. Morris - Versus Arthritis
Panos Deloukas - Queen Mary University of London
Gina Peloso - Boston University
Themistocles L. Assimes - Stanford University
Cristen J. Willer - University of Michigan–Ann Arbor
Xiang Zhu - Stanford University
Christopher D. Brown - University of Pennsylvania
Global Lipids Genetics Consortium
Publication Details: American journal of human genetics, Vol.109(8), pp.1366-1387
Publisher: Elsevier Inc
Date published: 04/08/2022
Identifiers: 99828362102346
Academic Unit: School of Biosciences
Language: English
Resource Type: Journal article

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

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