3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

Atabak Ghanizadeh Tabriz; Md Sadeque Mithu; Lilian Vilain; Youri Derrar; C Grau; Anaïs Morales; Orestis L. Katsamenis; Dennis Douroumis; Milan Antonijevic

doi:10.1016/j.ijpharm.2022.122574

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3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

Journal article

Peer reviewed

3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

Atabak Ghanizadeh Tabriz, Md Sadeque Mithu, Lilian Vilain, Youri Derrar, C Grau, Anaïs Morales, Orestis L. Katsamenis, Dennis Douroumis and Milan Antonijevic

International journal of pharmaceutics, Vol.632

05/02/2023

DOI: https://doi.org/10.1016/j.ijpharm.2022.122574

PMID: 36603670

Abstract

3D printing

Compartmental systems

LEGO®-like designs

Personalised treatment

3D printed LEGO®-like designs are an attractive approach for the development of compartmental delivery systems due to their potential for dose personalisation through the customisation of drug release profiles. Additive manufacturing technologies such as Fused Deposition Modelling (FDM) are ideal for the printing of structures with complex geometries and various sizes. This study is a paradigm for the fabrication of 3D printed LEGO® -like tablets by altering the design of the modular units and the filament composition for the delivery of different drug substances. By using a combination of placebo and drug loaded compartments comprising of immediate release (hydroxypropyl cellulose) and pH dependant polymers (hypromellose acetate succinate) we were able to customise the release kinetics of melatonin and caffeine that can potentially be used for the treatment of sleep disorders. The LEGO® -like compartments were designed to achieve immediate release of melatonin followed by variable lag times and controlled release of caffeine.

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Title: 3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder
Creators: Atabak Ghanizadeh Tabriz (Author) - Delta Pharmaceutics Ltd, 20 Steven Close, Chatham, Kent ME4 5NG, UK
Md Sadeque Mithu (Contributor) - Cubi-Tech Extrusion Ltd, 3 Sextant Park, Neptune Close, Rochester, Chatham, Kent ME2 4LU, UK
Lilian Vilain (Contributor) - Aix Marseille Université, Polytech Marseille, School of Engineering, 3 Avenue of Luminy, 13009 Marseille, France
Youri Derrar (Contributor) - Aix Marseille Université, Polytech Marseille, School of Engineering, 3 Avenue of Luminy, 13009 Marseille, France
C Grau (Contributor) - University of Haute-Alsace (UHA), School of Chemistry of Mulhouse (ENSCMu), 3 Street Alfred Werner, 68093 Mulhouse, France
Anaïs Morales (Contributor) - University of Haute-Alsace (UHA), School of Chemistry of Mulhouse (ENSCMu), 3 Street Alfred Werner, 68093 Mulhouse, France
Orestis L. Katsamenis (Contributor) - University of Southampton, μ-VIS X-ray Imaging Centre, Faculty of Engineering and Physical Sciences, Southampton SO17 1BJ, UK
Dennis Douroumis (Corresponding Author) - Delta Pharmaceutics Ltd, 20 Steven Close, Chatham, Kent ME4 5NG, UK
Milan Antonijevic (Other)
Publication Details: International journal of pharmaceutics, Vol.632
Publisher: Elsevier B.V
Date published: 05/02/2023
Date accepted: 29/12/2022
Grants: EP/T02593X/1, Engineering and Physical Sciences Research Council (United Kingdom, Swindon) - EPSRC
Grant note: Beamtime allocation at the μ-VIS X-ray Imaging Centre (www.muvis.org) was supported by the National Research Facility for Lab-based X-ray CT (nxct.ac.uk) through EPSRC grant EP/T02593X/1.
Identifiers: 99769066202346
Academic Unit: School of Chemistry and Chemical Engineering
Language: English
Resource Type: Journal article

3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

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