Abstract
Due to the rapid increase in workload, Clinical Biochemistry laboratories throughout the United Kingdom have experienced great difficulty in meeting the demands for everyday analyses. This has been partly met by the introduction of work-simplification and analytical machines. The first section of this work describes the development and testing of an automatic analytical system for the high speed performance of routine tests. The second section deals with the special problems encountered in providing a method for creatinine assay. This was unsuccessfully attempted with the use of enzymes but the problem was later solved by means of a kinetic approach to the traditional Jaffe reaction. The third section deals with the modification or development of certain chemical methods for use with the machine.