Chronic pathological skin picking is a prevalent and under-researched mental health condition with considerable biopsychosocial consequences for sufferers, including shame and social withdrawal. Current research lacks sufficient numbers of controlled studies, and the relative efficacy of different treatment options has been difficult to discern. Recent research has conceptualised skin picking as a form of experiential avoidance, leading to the development and testing of acceptance-enhanced behaviour therapy protocols in the skin picking population. Part A of this thesis therefore sought to ascertain the efficacy of currently available psychotherapeutic interventions for skin picking through a systematic review and meta-analysis. While intervention characteristics and the methodological quality of studies varied widely, meta-analytic findings tentatively suggested that psychotherapeutic interventions may reduce skin picking symptom severity and associated functional impairment. Part B of this thesis consists of an empirical study examining the feasibility, acceptability and preliminary efficacy of a brief acceptance-enhanced behaviour therapy intervention for skin picking in a pilot and feasibility randomised controlled trial. Findings suggest a medium effect of the intervention on skin picking symptom severity. Participants also rated the intervention as highly acceptable, highlighting the group setting as particularly helpful in reducing stigma and shame.