This book contains the proceedings of the 21st International Conference on Smart Business Technologies (ICSBT 2024). This year, ICSBT is held in collaboration with the ESEO, which hosts this event in Dijon, France, on July 9-11, 2024. It was sponsored by the Institute for Systems and Technologies of Information, Control and Communication (INSTICC). ICSBT 2024 was also organized in cooperation with the ACM Special Interest Group on Management Information Systems. The International Conference on Smart Business Technologies (formerly known as ICE-B - International Conference on e-Business), aims at bringing together researchers and practitioners who work on e-Business technology and its applications. The scope of the conference covers low-level technological issues, such as technology platforms, internet of things, artificial intelligence, data science and web services, but also higher-level issues, such as business processes, business intelligence, digital twins, value setting and business strategy. Furthermore, it covers different research approaches (like qualitative cases, experiments, forecasts, and simulations) to address these issues and different possible application domains (like manufacturing, service management and trade systems) with their own specific needs and requirements. We invite both more academic and practical oriented submissions, but we are especially interested in academic research with a potential practical impact and practical research papers with theoretical implications. ICSBT 2024 received 27 paper submissions from 13 countries of which 14.8% were accepted and published as full papers. A double-blind paper review was performed for each submission by at least 2 but usually 3 or more members of the International Program Committee, which is composed of established researchers and domain experts. The high quality of the ICSBT 2024 program is enhanced by the keynote lecture delivered by distinguished speakers who are renowned experts in their fields: Samuel Fosso Wamba (Toulouse Business School, France) and Sukhpal Singh Gill (Queen Many University of London, United Kingdom). All presented papers will be available at the SCITEPRESS Digital Library and will be submitted for evaluation for indexing by SCOPUS, Google Scholar, The DBLP Computer Science Bibliography, Semantic Scholar, Engineering Index and Web of Science / Conference Proceedings Citation Index. As recognition for the best contributions, several awards based on the combined marks of paper reviewing, as assessed by the Program Committee, and the quality of the presentation, as assessed by session chairs at the conference venue, are conferred at the closing session of the conference. Authors of selected papers will be invited to submit extended versions for inclusion in a forthcoming book of ICSBT Selected Papers to be published by Springer, as part of the CCIS Series. Some papers will also be selected for publication of extended and revised versions in the special issue of the Socio-Economic Planning Sciences and IMA Journal of Management Mathematics. The program for this conference required the dedicated effort of many people. Firstly, we must thank the authors, whose research efforts are herewith recorded. Next, we thank the members of the Program Committee and the auxiliary reviewers for their diligent and professional reviewing. We would also like to deeply thank the invited speakers for their invaluable contribution and for taking the time to prepare their talks. Finally, a word of appreciation for the hard work of the INSTICC team; organizing a conference of this level is a task that can only be achieved by the collaborative effort of a dedicated and highly competent team. We wish you all an exciting and inspiring conference. We hope to have contributed to the development of our research community, and we look forward to having additional research results presented at the next edition of ICSBT, details of which are available at https://icsbt.scitevents.org.