Abstract
Oestradiol (E2) has been shown to exert a significant influence on neurometabolites in the brain, impacting neurotransmitter synthesis, neurosteroid production, energy metabolism, oxidative stress levels, and neurotransmitter metabolism. However, underrepresentation of women in experimental samples has prevented critical understanding of hormonal fluctuations on neurochemistry, and the capacity of exogenous hormone treatment (HRT) to mediate brain ageing post menopause. Here we employ magnetic resonance spectroscopy (MRS) to investigate the influence of HRT on several brain metabolites, as proxy measures of neural integrity, neuronal/glial membrane turnover and function.
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