Abstract
The purpose of this investigation was to measure the inflammatory response of the joint capsule to PE wear debris in a non-loose canine hip arthroplasty model. Results indicate that in the absence of loosening the joint capsule tolerated the continued production of PE wear debris without initiating a progressive inflammatory response. We propose that this may be due to the rate of particulate production being accommodated by the tissue by its ability to clear the wear debris. The amount of wear debris generated in our model was not sufficient to initiate progressive inflammation and/or loosening of the prothesis.