People with dementia were disproportionately impacted by the COVID-19 pandemic. The effects of lockdown measures and restrictions, combined with staffing shortages and working conditions in care homes, were associated with deterioration in the health and wellbeing of residents. Culture Box was a research project that used arts-based approaches to improve wellbeing for people living with dementia in care homes during the time of COVID-19 restrictions. For twelve months, the project sent out boxes containing interactive creative resources and activities for residents and care staff to complete in dyads or groups. This chapter considers the effect of the creative resources and some of the lessons learnt from undertaking an innovative study during a global pandemic.