The development of artificial intelligence (AI) algorithms for classification purpose of undesirable events has gained notoriety in the industrial world. Nevertheless, for AI algorithm training is necessary to have labeled data to identify the normal and anomalous operating conditions of the system. However, labeled data is scarce or nonexistent, as it requires a herculean effort to the specialists of labeling them. Thus, this chapter provides a comparison performance of six unsupervised Machine Learning (ML) algorithms to pattern recognition in multivariate time series data. The algorithms can identify patterns to assist in semiautomatic way the data annotating process for, subsequentially, leverage the training of AI supervised models. To verify the performance of the unsupervised ML algorithms to detect interest/anomaly pattern in real time series data, six algorithms were applied in following two identical cases (i) meteorological data from a hurricane season and (ii) monitoring data from dynamic machinery for predictive maintenance purposes. The performance evaluation was investigated with seven threshold indicators: accuracy, precision, recall, specificity, F1-Score, AUC-ROC and AUC-PRC. The results suggest that algorithms with multivariate approach can be successfully applied in the detection of anomalies in multivariate time series data.