Abstract
This chapter discusses how a neuroconstructivist, multidisciplinary approach enriches our understanding of neurodevelopmental disorders. The neuroconstructivist approach raises cross-syndrome questions at multiple levels of analysis, such as: is this brain/cognitive/behavioural deficit syndrome-specific or is it syndrome-general, that is, is it characteristic of all atypical development where learning difficulties obtain or unique to a particular syndrome? It differentiates domain-relevant mechanisms from domain-specific or domain-general ones. It also searches for very low-level impairments in the neonate profile — at the levels of brain, cognition, and behaviour — that might affect gene expression and have cascading effects on developmental outcomes.