Abstract
The relationship between circadian biology and metabolism has been elegantly described in animal and cellular models. However, the translational benefit of this work relies on the findings of human studies. This research involves highly controlled laboratory protocols in addition to interventions within free-living people. The presentation will describe how many aspects of human metabolism change over the day in healthy volunteers, together with the effect of obesity and type 2 diabetes on these rhythms. The role of the endogenous circadian system in daily metabolic rhythms will then be identified. Finally, the presentation will explore the 2-way interaction between the human circadian system and meal timing. Both published and currently unpublished data will be included.